Resumes
Resumes
Chandra Sehgal Phones & Addresses
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612 Wallace Dr, Wayne, PA 19087 (610) 688-5216
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Strafford, PA
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Jersey City, NJ
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Rochester, MN
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Brooklyn, NY
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Philadelphia, PA
Work
Position:
Professional/Technical
Education
Degree:
Associate degree or higher
Publications
Us Patents
Method And Apparatus To Control Microbubble Destruction During Contrast-Enhanced Ultrasound Imaging, And Uses Therefor
View pageUS Patent:
6858011, Feb 22, 2005
Filed:
Sep 23, 2002
Appl. No.:
10/252642
Inventors:
Chandra M. Sehgal - Wayne PA, US
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61B008/14
US Classification:
600458
Abstract:
Methods and apparatus are provided for controlling fluid flow or perfusion, wherein gas-filled microbubbles are used as ultrasound contrast-enhancing agents, and wherein the method comprises separating the removal of the contrast agent due to flow from the removal of the contrast agent due to bubble destruction for enhanced imaging processes. By varying exposure of the microbubbles to ultrasound, the method and apparatus apply the changes observed in the images to measure flow and vascularity, to improve visualization of blood flow and blood vessels, and to guide delivery of drugs locally to the site of imaging.
Use Of Ultrasound As An Antivascular Agent
View pageUS Patent:
20100041989, Feb 18, 2010
Filed:
Oct 1, 2007
Appl. No.:
12/442597
Inventors:
Chandra Sehgal - Wayne PA, US
Andrew K. W. Wood - Philadelphia PA, US
Andrew K. W. Wood - Philadelphia PA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
International Classification:
A61N 7/00
A61B 8/00
A61B 8/00
US Classification:
600439, 601 2
Abstract:
A method for detecting and disrupting fragile blood vessels formed as a result of tumor angiogenesis by manipulating an extent of tissue vascularity in vivo, the method includes targeting a region in need of manipulating the extent of vascularity of the tissue by a diagnostic imaging; visualizing said fragile blood vessels in the tissue; obtaining a characteristic of the tissue; and contacting the tissue with a therapeutic ultrasound producing an unfocused or mildly focused ultrasound beam having an intensity below 2.6 W/cm2, wherein the therapeutic ultrasound is emitted from an ultrasound unit in accordance with the characteristic of the tissue and thereby reducing the extent of vascularity of the tissue and disrupting said fragile blood vessels formed to support the tumor in the region of interest.
Methods And Systems For Image-Guided Treatment Of Blood Vessels
View pageUS Patent:
20120116221, May 10, 2012
Filed:
Apr 9, 2010
Appl. No.:
13/263133
Inventors:
Chandra Sehgal - Wayne PA, US
Andrew Kenneth Wood - Philadelphia PA, US
Andrew Kenneth Wood - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61N 7/00
A61B 8/00
A61B 8/00
US Classification:
600439
Abstract:
Methods and systems of treating at least one blood vessel involves the application of therapy ultrasound to the blood vessel(s) using one or more dosing conditions. An image of the region of interest is acquired responsive to the applied therapy ultrasound. A change in vascularity of the blood vessel(s) is estimated, responsive to the applied therapy ultrasound, using the acquired image to determine whether to adjust at least one of the dosing conditions. The therapy ultrasound is applied with an intensity to modify the blood vessel(s) without damaging a surrounding tissue. A method of treating a tumor comprises introducing a therapeutic agent into a bloodstream and applying therapy ultrasound to blood vessel(s). The therapy ultrasound, along with an agent, disrupts the blood vessel(s) to limit flow to and from the tumor, thereby retaining the therapeutic agent within the tumor.
Microfluidic-Based Generation Of Functionalized Microbubbles For Ultrasound Imaging And Therapy
View pageUS Patent:
20120328529, Dec 27, 2012
Filed:
Aug 5, 2010
Appl. No.:
13/388858
Inventors:
Daeyeon Lee - Wynnewood PA, US
Chandra M. Sehgal - Wayne PA, US
Myung Han Lee - Seoul, KR
Chandra M. Sehgal - Wayne PA, US
Myung Han Lee - Seoul, KR
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
International Classification:
A61K 49/22
A61K 9/14
A61K 9/00
A61K 9/14
A61K 9/00
US Classification:
424 95, 424400, 264 4
Abstract:
A method for generating stable encapsulated bubbles and dried encapsulated bubbles comprises introducing an inner stream of a gas into a liquid-filled chamber from an exit orifice of a capillary tube; introducing a middle stream of a water immiscible liquid into the exit orifice; and introducing an outer stream of an aqueous liquid to the exit orifice, to form compound bubbles. The encapsulated bubbles are formed after converting the middle phase of compound bubbles into a shell. The stable encapsulated bubbles or the stable dried encapsulated bubbles can be used in drug delivery and for enhancing ultrasound imaging.
Automatic Quantification Of Mitral Valve Dynamics With Real-Time 3D Ultrasound
View pageUS Patent:
20130195335, Aug 1, 2013
Filed:
Feb 25, 2011
Appl. No.:
13/580833
Inventors:
Robert C. Gorman - Lower Gwynedd PA, US
Alison Pouch - Philadelphia PA, US
Chandra Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Benjamin Jackson - Wynnewood PA, US
Alison Pouch - Philadelphia PA, US
Chandra Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Benjamin Jackson - Wynnewood PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G06T 7/00
US Classification:
382131
Abstract:
A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
Apparatus For Imaging An Element Within A Tissue And Method Therefor
View pageUS Patent:
5997477, Dec 7, 1999
Filed:
Apr 14, 1997
Appl. No.:
8/837160
Inventors:
Chandra Sehgal - Wayne PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61B 800
US Classification:
600437
Abstract:
Methods and apparatus for detecting microcalcifications in breasts. The methods and apparatus will greatly improve detection of breast microcalcifications and concomitantly increase the early detection of breast cancers. The methods and apparatus described herein activate the resonance frequency of a breast microcalcification, thereby allowing for detection of small masses.
Ultrasound Responsive Microbubbles And Related Methods
View pageUS Patent:
20220288227, Sep 15, 2022
Filed:
Mar 15, 2022
Appl. No.:
17/695612
Inventors:
- Philadelphia PA, US
Daeyeon Lee - Wynnewood PA, US
Chandra M Sehgal - Wayne PA, US
Daniel A Hammer - Villanova PA, US
Daeyeon Lee - Wynnewood PA, US
Chandra M Sehgal - Wayne PA, US
Daniel A Hammer - Villanova PA, US
International Classification:
A61K 47/69
A61K 41/00
A61K 9/00
A61K 45/06
A61K 41/00
A61K 9/00
A61K 45/06
Abstract:
A microbubble composition, comprising: a plurality of microbubbles, a microbubble comprising a noble gas and/or perfluorocarbon encapsulated within a shell that comprises one or more of a lipid, a protein, or a polymer, and a microbubble optionally defining a cross-sectional dimension in the range of from about 0.5 to about 20 micrometers. A method, comprising forming a composition according to the present disclosure. A method, comprising administering a microbubble composition according to the present disclosure to a subject, the composition optionally comprising echogenic phospholipid microbubbles. A method, comprising: (a) identifying, with the application of energy, the location of a microbubble composition according to the present disclosure, the energy optionally being ultrasound, (b) controllably effecting rupture of microbubbles of a microbubble composition of the present disclosure, the rupture optionally being effected by application of ultrasound, or both (a) and (b).
Semi-Automated Heart Valve Morphometry And Computational Stress Analysis From 3D Images
View pageUS Patent:
20200394798, Dec 17, 2020
Filed:
Aug 24, 2020
Appl. No.:
17/000515
Inventors:
- Philadelphia PA, US
Robert C. Gorman - Lower Gwynedd PA, US
Alison M. Pouch - Philadelphia PA, US
Chandra M. Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Brian B. Avants - Philadelphia PA, US
Hongzhi Wang - Boiling Springs PA, US
Robert C. Gorman - Lower Gwynedd PA, US
Alison M. Pouch - Philadelphia PA, US
Chandra M. Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Brian B. Avants - Philadelphia PA, US
Hongzhi Wang - Boiling Springs PA, US
International Classification:
G06T 7/00
G06T 7/13
A61B 8/08
A61B 8/12
G06F 30/23
G06K 9/46
G06K 9/52
G06K 9/62
G06T 3/40
G06T 7/60
G06T 7/13
A61B 8/08
A61B 8/12
G06F 30/23
G06K 9/46
G06K 9/52
G06K 9/62
G06T 3/40
G06T 7/60
Abstract:
A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape. The regional leaflet stress distributions may be predicted in normal and diseased (regurgitant) mitral valves using the techniques of the invention.