Inventors:
Rajinder Singh - Belmont CA, US
Ankush Argade - Foster City CA, US
Hui Li - Millbrae CA, US
Somasekhar Bhamidipati - Foster City CA, US
David Carroll - San Francisco CA, US
Catherine Sylvain - San Mateo CA, US
Jeffrey Clough - Redwood City CA, US
Holger Keim - Menlo Park CA, US
Assignee:
Rigel Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
C07D 401/14
C07D 403/14
C07D 413/14
C07D 417/14
A61K 31/506
A61K 31/4523
A61K 31/5377
A61K 31/541
A61P 19/02
A61P 37/00
US Classification:
5142315, 514272, 514274, 51425213, 5142272, 51421001, 51421101, 51421201, 544320, 544323, 544324, 544111, 544 60, 540484, 540450
Abstract:
The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.