US Patent:
20110177963, Jul 21, 2011
Inventors:
Geoffrey L. Chupp - Madison CT, US
Jack A. Elias - Woodbridge CT, US
Carole Ober - Chicago IL, US
International Classification:
C40B 30/04
C12Q 1/68
G01N 33/559
G01N 33/53
US Classification:
506 9, 435 61, 435 612, 435 611, 436515, 435 792
Abstract:
The present invention is based on the discovery that a single nucleotide polymorphism (SNP) present the chitinase 3-like 1 gene (CHI3L1) encoding YKL-40 or a regulatory domain of the CHI3L1 gene, is associated with elevated YKL-40 levels, as well as an increased risk for developing a lung disorder, including asthma, bronchial hyperresponsivity, and/or reduced lung function.