Search

Carol G Waghorne

from Sanbornville, NH
Age ~73

Carol Waghorne Phones & Addresses

  • 151 Michawanic Rd UNIT 5D, Sanbornville, NH 03872 (603) 669-8017
  • Saint Augustine, FL
  • Somerville, MA
  • Lexington, MA
  • 195 Tory Rd, Manchester, NH 03104 (603) 669-8017
  • 35 Andrew St, Manchester, NH 03104 (603) 627-4120
  • 543 Lincoln St, Manchester, NH 03104 (603) 627-4120
  • Brookline, MA

Work

Company: Arqule May 2008 Position: Lead investigator biomarker group

Education

Degree: MMSc School / High School: Harvard Medical School 2006 to 2008 Specialities: Scholars in Clinical Sciences

Skills

Molecular Biology • Biomarkers • Biochemistry • Cancer • Assay Development • Drug Discovery • Biotechnology • Cell Biology • Lifesciences • Cancer Research • Western Blotting • Pharmacology • Cell Culture • Genomics • Immunohistochemistry

Industries

Research

Resumes

Resumes

Carol Waghorne Photo 1

Senior Curator

View page
Location:
151 Michawanic Rd, Sanbornville, NH 03872
Industry:
Research
Work:
ArQule since May 2008
Lead Investigator Biomarker Group

Harvard Medical School Jun 2006 - May 2008
Scholars in Clinical Sciences

Brigham and Women's Hospital May 2006 - May 2008
Research Fellow

Harvard Medical School Sep 2005 - 2007
Tutor

Children's Hospital Oct 2003 - May 2006
Research Fellow
Education:
Harvard Medical School 2006 - 2008
MMSc, Scholars in Clinical Sciences
University of Toronto 1977 - 1984
PhD, Medical Genetics
University of Guelph 1971 - 1975
BSc (Honors), Biological Sciences
Skills:
Molecular Biology
Biomarkers
Biochemistry
Cancer
Assay Development
Drug Discovery
Biotechnology
Cell Biology
Lifesciences
Cancer Research
Western Blotting
Pharmacology
Cell Culture
Genomics
Immunohistochemistry

Publications

Us Patents

Phosphorylated Nf45 Biomarkers, Antibodies And Methods Of Using Same

View page
US Patent:
20120021432, Jan 26, 2012
Filed:
Apr 15, 2011
Appl. No.:
13/087457
Inventors:
Yi Yu - Malden MA, US
Xiubin Gu - Wilmington MA, US
Xiaolan Zhao - Andover MA, US
Carol Waghorne - Lexington MA, US
Thomas C.K. Chan - Winchester MA, US
Taiping Chen - Andover MA, US
Assignee:
ArQule, Inc. - Woburn MA
International Classification:
G01N 33/566
C07K 16/18
C07K 14/435
G01N 21/64
US Classification:
435 71, 436501, 5303879, 530352
Abstract:
The present invention relates to isolated phosphorylated NF45 peptides and isolated phosphorylation site-specific antibody or antigen-binding portion thereof that specifically binds a phosphorylated NF45 protein. The present invention also relates to methods of utilizing these antibodies to determine the therapeutic efficacy of a candidate compound and methods for screening for candidate compounds that increase the phosphorylation of NF45 protein in a cell.

Method For Determining Treatment Efficacy

View page
US Patent:
20110301194, Dec 8, 2011
Filed:
Jun 1, 2011
Appl. No.:
13/150295
Inventors:
Thomas C.K. Chan - Winchester MA, US
Carol Waghorne - Lexington MA, US
Giovanni Abbadessa - Boston MA, US
Assignee:
ArQule, Inc. - Woburn MA
International Classification:
A61K 31/4709
A61P 35/00
G01N 33/68
US Classification:
514314, 436 86
Abstract:
The present invention provides a method for determining the efficacy of a c-Met inhibitor in treating a cell proliferative disorder, comprising: a) administering to a subject in need thereof a therapeutically effective amount of the c-Met inhibitor, or a pharmaceutically acceptable salt, prodrug or metabolite thereof, either alone or in combination with a therapeutically effective amount of a second anti-proliferative agent; and b) measuring the concentration of hepatocyte growth factor (HGF) in the serum from the subject, wherein if the concentration of serum HGF does not decrease, or if the concentration of serum HGF increases, the c-Met inhibitor is efficacious in treating the cell proliferative disorder.
Carol G Waghorne from Sanbornville, NH, age ~73 Get Report