US Patent:
20020110563, Aug 15, 2002
Inventors:
Steven Reed - Bellevue WA, US
Michael Lodes - Seattle WA, US
Raodoh Mohamath - Seattle WA, US
Heather Secrist - Seattle WA, US
Darin Benson - Seattle WA, US
Carol Indirias - Seattle WA, US
Robert Henderson - Edmonds WA, US
Steven Fling - Bainbridge Island WA, US
Paul Algate - Issaquah WA, US
Mark Elliott - Seattle WA, US
Jane Mannion - Edmonds WA, US
Michael Kalos - Seattle WA, US
International Classification:
C12Q001/68
G01N033/574
C07H021/04
A61K039/395
C12P021/02
C12N005/06
US Classification:
424/155100, 435/006000, 435/007230, 435/069100, 435/183000, 435/325000, 435/320100, 536/023100
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.