Carl M Schoellhammer

20130165772, Jun 27, 2013

Dec 27, 2012

13/728300

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA, US
THE GENERAL HOSPITAL CORPORATION - Boston MA, US
Baris Erinc Polat - Brighton MA, US
Carl Magnus Schoellhammer - Santa Monica CA, US
Daniel Blankschtein - Brookline MA, US
Daniel G. Anderson - Sudbury MA, US
Robert S. Langer - Newton MA, US

THE GENERAL HOSPITAL CORPORATION - Boston MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA

A61M 37/00
A61M 5/00

600431, 604173, 604506, 604 22, 604 20, 600 9

The present disclosure provides devices and uses thereof A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

20200197538, Jun 25, 2020

May 14, 2018

16/612648

- Cambridge MA, US
George M. Church - Brookline MA, US
Noah Davidsohn - Brookline MA, US
Carl Schoellhammer - Medford MA, US
Robert S. Langer - Newton MA, US
Carlo Giovanni Traverso - Newton MA, US

A61K 48/00
A61K 47/69
C12N 15/86
A61N 7/00

A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

20190111130, Apr 18, 2019

Oct 16, 2018

16/162060

- Cambridge MA, US
- Boston MA, US
Dan Minahan - Weymouth MA, US
Taylor A. Bensel - Boston MA, US
Thomas von Erlach - Somerville MA, US
Carl Magnus Schoellhammer - Medford MA, US

A61K 41/00
A61K 9/00
A61P 1/00
G01N 1/28
A61M 37/00

Disclosed herein are compositions comprising a pharmaceutical agent and an ultrasound enhancing agent. The compositions are useful in combination with ultrasound to enhance delivery of a pharmaceutical agent to, for example, tissue of a subject in need thereof. Accordingly, also provided herein are methods involving ultrasound for delivering a pharmaceutical agent to a subject, e.g., a subject that has inflammatory bowel disease or proctitis.

20180055991, Mar 1, 2018

Oct 6, 2017

15/727015

Carl Magnus SCHOELLHAMMER - Somerville MA, US
Carlo Giovanni TRAVERSO - Newton MA, US
Avraham SCHROEDER - Binyamina, IL
Baris POLAT - Pittsburgh PA, US
Daniel BLANKSCHTEIN - Brookline MA, US
Robert S. LANGER - Newton MA, US
William BRUGGE - Boston MA, US

A61M 3/02
A61M 37/00
A61M 31/00

Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

20140228715, Aug 14, 2014

May 14, 2012

14/116628

- Boston MA, US
- Cambridge MA, US
Baris E. Polat - Brighton MA, US
Kathryn A. Whitehead - Somerville MA, US
Daniel G. Anderson - Sudbury MA, US
Carl Magnus Schoellhammer - Santa Monica CA, US
Daniel Blankschtein - Brookline MA, US

The General Hospital Corporation - Boston MA
Massachusetts Institute of Technology - Cambridge MA

A61N 7/00

601 2

A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.