Carl Munger Good

58539948, Dec 29, 1998

Dec 5, 1996

8/761739

Gopal Gopinathan - Cary NC
Edmund F. Becker - Lexington MA
William Wong - Milton MA
Qiang Xue - Salem MA
Carl M. Good - Groton MA
John Fallon - Andover MA
Xue-Song Li - Lexington MA

Analogic Corporation - Peabody MA

G01N 33546

435 6

A system for assaying a fluid sample for one or more types of analytes, which employs at least one class of finely divided polystyrene spheroidal particles, each class being limited to a predetermined specific narrow range of particle diameters, the particles of each such class being coated with a specific reactant unique for that class. After the coated particles are mixed with the sample to specifically react to form conjugates of the particles and any of the analyte present, the mixture is irradiated with bursts of ultrasound swept over a range of frequencies resonant to the expected conjugate sizes. The presence of the conjugates and therefore the analyte is detected directly by measuring any selective absorption or scattering of waves of frequencies to which the conjugates are resonant.

61942243, Feb 27, 2001

Jul 27, 1998

9/123376

Carl M. Good - Groton MA
Shirley Smith - Key Biscayne FL

Avitar, Inc. - Canton MA

C12Q 128
G01N 33543
G01N 2178
G01N 3300

436518

A diagnostic test strip for determining the presence of a specified analyte in a fluid sample is described. The test strip has a test membrane sandwiched between two layers of a plastic sheath. The upper layer of the sheath has a sample well into which a liquid sample is placed. The test membrane has a sample receiving zone typically containing a buffer and a fatty acid sarcosinate. Adjacent to the sample receiving zone is a reagent zone containing reagent chemicals including gold colloid particles coated with antibodies to the specified analyte. In fluid connection with the reagent zone is a test zone containing immobilized molecules of the specified analyte. Preferably, in fluid connection with the test zone is a control zone containing an indicator that changes color when wetted by the sample and a liquid sink zone to absorb excess liquid in the sample.