Brian E Macconaghy

20200209115, Jul 2, 2020

Feb 25, 2020

16/801087

- Kirkland WA, US
Greg P. Darlington - Snohomish WA, US
Brian E. MacConaghy - Seattle WA, US
Thomas J. Matula - Kirkland WA, US
Adam D. Maxwell - Lynwood WA, US

Matchstick Technologies, Inc. - Kirkland WA
University of Washington - Seattle WA

G01N 1/28
H01L 41/187
B06B 1/02
H01L 41/04
B06B 1/06
C12Q 1/6806
C12M 1/00
G10K 11/30
C12N 13/00

Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting example, an illustrative piezoelectric element array assembly includes at least one piezoelectric element configured to produce ultrasound energy responsive to amplified driving pulses. A lens layer is bonded to the at least one piezoelectric element. The lens layer has a plurality of lenses formed therein that are configured to focus ultrasound energy created by single ones of the at least one piezoelectric element into a plurality of wells of a microplate disposable in ultrasonic communication with the lens layer, wherein more than one of the plurality of lenses overlie single ones of the at least one piezoelectric element.

20190282201, Sep 19, 2019

Oct 17, 2018

16/163308

- Seattle WA, US
Samuel R. Browd - Seattle WA, US
Brian MacConaghy - Kent WA, US
Revathi Murthy - Herndon VA, US
Nathaniel Coulson - Liberty Lake WA, US

University of Washington through its Center for Commercialization - Seattle WA

A61B 8/08
A61B 8/00
A61B 17/34
A61M 25/09
A61B 8/12
A61B 17/00

A stylet includes a handle assembly with an indicator display and a stiff wire assembly extending distally from the handle assembly having a non-imaging ultrasonic device on a distal end. The stylet includes a circuit assembly having one or more of a pulser, a transmit/receive chip, a bandpass filter, a differential amplifier, an ADC, and an MCU, operable to control the operation of the ultrasonic device and to receive and analyze data from the ultrasonic device to facilitate implantation of a device such as a catheter.

20180209878, Jul 26, 2018

Jan 17, 2018

15/873857

- Kirkland WA, US
Brian E. MacConaghy - Seattle WA, US
Greg P. Darlington - Snohomish WA, US
Karol Bomsztyk - Mercer Island WA, US
Adam D. Maxwell - Lynwood WA, US

Matchstick Technologies, Inc. - Kirkland WA
University of Washington - Seattle WA

G01N 1/28
C12Q 1/6806
B06B 1/06
H01L 41/04
H01L 41/187
B06B 1/02

Disclosed embodiments include illustrative piezoelectric element array assemblies, methods of fabricating a piezoelectric element array assembly, and systems and methods for shearing cellular material. Given by way of non-limiting example, an illustrative piezoelectric element array assembly includes at least one piezoelectric element configured to produce ultrasound energy responsive to amplified driving pulses. A lens layer is bonded to the at least one piezoelectric element. The lens layer has a plurality of lenses formed therein that are configured to focus ultrasound energy created by single ones of the at least one piezoelectric element into a plurality of wells of a microplate disposable in ultrasonic communication with the lens layer, wherein more than one of the plurality of lenses overlie single ones of the at least one piezoelectric element.

20170328834, Nov 16, 2017

Apr 4, 2017

15/478953

- Seattle WA, US
Andrew A. Brayman - Edmonds WA, US
Oleg A. Sapozhnikov - Seattle WA, US
Brian MacConaghy - Kent WA, US
Jarred Egan Swalwell - Shoreline WA, US
Camilo Perez - Seattle WA, US

University of Washington - Seattle WA

G01N 21/53
B01L 3/00
G01N 21/64
B01L 3/00
G01N 1/40
G01N 21/64
B01L 3/00
G01N 1/40
G01N 15/10

Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.

20170205318, Jul 20, 2017

Jul 14, 2015

15/326892

- Seattle WA, US
Karol Bomsztyk - Mercer Island WA, US
Brian MacConaghy - Kent WA, US
Justin Reed - Seattle WA, US
Adam D. Maxwell - Woodinville WA, US

University of Washington - Seattle WA

G01N 1/28
B01L 3/00
B06B 1/02
G10K 11/30
B06B 1/06

A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.

20150251141, Sep 10, 2015

Nov 5, 2013

14/440641

- Seattle WA, US
Jaffer Alali - Redmond WA, US
Brian Macconaghy - Kent WA, US

University of Washington Through Its Center for Commercialization - Seattle WA

B01D 71/68
B01D 71/56
C02F 1/44
B01D 71/02
B01D 71/34
B01D 65/08
B01D 61/00

Described herein are apparatuses and methods for preventing or otherwise reducing scaling and fouling of a membrane using ultrasonic vibrations. One example method involves: (1) directing a solution to a membrane of a membrane assembly, where the membrane passes a solvent of the solution through the membrane at a first rate, and where the membrane prevents at least some of a solute of the solution from passing through the membrane; and (2) causing a piezoelectric material that is physically coupled to the membrane to produce ultrasonic waves directed at the membrane, where the ultrasonic waves induce oscillations in at least a portion of the membrane and thereby the solvent of the solution passes through the membrane at a second rate that is greater than the first rate.

20150142007, May 21, 2015

May 17, 2013

14/399143

- Seattle WA, US
Michael R. Bailey - Seattle WA, US
James M. Hotaling - Chicago IL, US
Brian Macconaghy - Kent WA, US
Francis Olson - Seattle WA, US

A61B 17/326

606118

The present technology relates generally to surgical devices for male circumcision and associated systems and methods. In some embodiments, a circumcision device configured in accordance with the technology comprises an outer member configured to be positioned along an exterior portion of a prepuce adjacent a glans of a penis of a human patient. The outer member may include an open-ended band moveable between an unlocked position and a plurality of locked positions. The band includes circumferentially overlapping first and second ends in each of the locked positions, and defines a closed space having a different fixed diameter in each of the locked positions. The device can also include a cylindrical inner member configured to be positioned within the band of the outer member and adjacent an inner portion of the prepuce.

20150017678, Jan 15, 2015

Apr 16, 2014

14/254611

- Seattle WA, US
Andrew A. Brayman - Edmonds WA, US
Oleg A. Sapozhnikov - Seattle WA, US
Brian MacConaghy - Kent WA, US

University of Washington Through Its Center for Commercialization - Seattle WA

G01N 1/31
G01N 21/53
G01N 21/63
G01N 21/64

435 30, 4352831, 4352887, 4352871

Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example, the acoustic properties of the cells of interest may be modified by attaching bubbles to the cells of interest. The cell sample may then be subjected to an acoustic wave. The cells of interest may be differentiated and/or separated from the remainder of the sample based on relative displacements and/or volumetric changes experienced by the cells of interest in response thereto. The cells of interest may be separated using a standing wave and sorted into separate channels of a flow cell. Optionally, the cells may be interrogated by a light source and differentiated by signals generated in response thereto.