US Patent:
20180125620, May 10, 2018
Inventors:
- Pittsburgh PA, US
Linda Cahalan - Cape Coral FL, US
Greg Johnson - Pittsburgh PA, US
Mark Gartner - Wexford PA, US
Patrick Cahalan - Cape Coral FL, US
Brian J. Fill - Pittsburgh PA, US
Jeffrey W. Speakman - Saxonburg PA, US
International Classification:
A61C 15/04
A61L 31/04
A61B 17/06
Abstract:
A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.