Brett A Trauthen

6458069, Oct 1, 2002

Aug 24, 1999

09/382302

Lisa A. Tam - Lake Forest CA
Brett A. Trauthen - Newport Beach CA

Endology, INC. - Irvine CA

A61N 500

600 3

A sealed radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.

6491619, Dec 10, 2002

Aug 25, 2000

09/648563

Brett Trauthen - Newport Beach CA
Lisa Tam - Lake Forest CA
Robert Fazio - Yorba Linda CA
Michael Crocker - Anaheim CA
Edward F. Smith - Los Flores CA
Gary Strathern - Santa Monica CA

Endologix, Inc - Irvine CA

A61N 500

600 3

Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.

6685618, Feb 3, 2004

Aug 31, 2001

09/944649

Lisa A. Tam - Lake Forest CA
Brett A. Trauthen - Newport Beach CA

Endologix, Inc. - Irvine CA

A61N 500

600 3

Disclosed is a thin film radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.

7686846, Mar 30, 2010

Apr 19, 2007

11/737652

Jean-Claude Laborde - Vieille-Toulouse, FR
Robert John Elicker - Santa Margarita CA, US
Brett Trauthen - Newport Beach CA, US
Jacques Seguin - Windsor, GB

Devax, Inc. - Irvine CA

A61F 2/06

623 135, 128898

A method of deploying a bifurcation stent at a vascular bifurcation of a main vessel into first and second branch vessels includes: positioning a bifurcation stent at a vascular bifurcation, the bifurcation stent expandable from a reduced diameter to an expanded diameter, the bifurcation stent comprising a first end, a second end, and a marker near the first end, wherein the first end diameter is larger than the second end diameter when the bifurcation stent is expanded, and wherein the bifurcation stent is positioned such that the marker is approximately aligned with a carinal plane at the vascular bifurcation; partially expanding the first end of the bifurcation stent; adjusting the position of the bifurcation stent such that the marker is positioned past the carinal plane and towards the first branch vessel; and deploying the bifurcation stent at the bifurcation. Devices are also disclosed.

20030163017, Aug 28, 2003

Oct 1, 2002

10/262639

Lisa Tam - Lake Forest CA, US
Brett Trauthen - Newport Beach CA, US

A61N005/00

600/003000

Disclosed is a sealed radiation source, which may be used to deliver a radioactive dose to a site in a body lumen. The source comprises a thin flexible substrate, and a layer of radioisotope attached thereto. The source may further comprise additional layers such as one or more tie layers disposed between the substrate and the radioisotope layer and one or more outer coating layers. In one embodiment, the source is wrapped around an inflatable balloon. Inflation of the balloon at a treatment site positions the source directly adjacent to the vessel wall, and allows irradiation of the site following or simultaneously with a balloon angioplasty, stent implantation, or stent sizing procedure.

20030166990, Sep 4, 2003

Dec 9, 2002

10/314894

Brett Trauthen - Newport Beach CA, US
Lisa Tam - Lake Forest CA, US
Robert Fazio - Yorba Linda CA, US
Michael Crocker - Anaheim CA, US
Edward Smith - Los Flores CA, US
Gary Strathern - Santa Monica CA, US

A61N005/00

600/003000

Disclosed are sources and methods for delivering a radioactive dose to a site in a body lumen. The sources are preferably mounted on a balloon or other expandable or deployable mechanical structure. The source and methods enable delivery of a clinically significant dose of radiation into a vessel wall in a relatively short time while using a relatively low activity. The sources also enable delivery of a substantially uniform dose into the vessel wall, whether or not such delivery is through the wall of a stent.

20040204756, Oct 14, 2004

Feb 11, 2004

10/777881

Stephen Diaz - Palo Alto CA, US
Theodore Parker - Danville CA, US
John Shanley - Redwood City CA, US
Brett Trauthen - Newport Beach CA, US
Frank Litvack - Los Angeles CA, US

A61F002/06

623/001420

A-00010

20060178734, Aug 10, 2006

Jan 4, 2006

11/325223

Theodore Parker - Danville CA, US
John Shanley - Redwood City CA, US
Brett Trauthen - Newport Beach CA, US
Frank Litvack - Los Angeles CA, US
Stephen Diaz - Palo Alto CA, US

Conor Medsystems, Inc. - Menlo Park CA

A61F 2/06

623001420

A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended, and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent per day throughout an entire administration period from the time of implantation of the stent until the time that substantially all the paclitaxel is released from the stent.