Inventors:
- Brentford, GB
Yao CHEN - Collegeville PA, US
Mark HURLE - Collegeville PA, US
Craig LEACH - Collegeville PA, US
Brandon TURUNEN - Collegeville PA, US
International Classification:
A61K 31/454
A61K 31/4375
A61K 31/438
A61K 31/496
A61K 31/506
A61K 31/5375
A61K 31/5377
A61K 31/499
Abstract:
The present invention relates to non peptidic, heterobivalent molecules (HBM) that are able to simultaneously bind a surface target protein as well as an endogenous or exogenous human antibody protein and induce immune effector function. More specifically, the present invention relates to agents capable of binding to a chemokine receptor and inducing the depletion of chemokine receptor positive subsets of pathogenic cells in a subject for use in the treatment and/or prevention of cancer, inflammatory, autoimmune and allergic disease.