Inventors:
Binhui Ni - Carmel IN
Marc Paul - Carmel IN
Xin Wu - Carmel IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C12N 948
C12N 964
C12N 914
C12Q 137
Abstract:
The present invention provides for a novel ICE related protease and nucleic acids coding same. The present invention also provides a method to isolate an ICE related protease and related DNA compounds encoding this protease. The present invention further comprises a method using said protease to screen for inhibitors of apoptosis. Additionally, the invention further comprises a method of using said inhibitors of apoptosis in the treatment in human patients with the acquired disease states of brain ischemia, stroke, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), head trauma, or other neurodegenerative disorders.