Joseph E. Lynch - Plainfield NJ Ralph P. Volante - East Windsor NJ William L. Laswell - Perkasie PA Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C25B 300
US Classification:
204 59R
Abstract:
The 4-acryloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by electrochemical methods.
Joseph E. Lynch - Plainfield NJ William L. Laswell - Perkasie PA Ralph P. Volante - East Windsor NJ Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D40704 C07D20508 C07B 4114 C07F 718
US Classification:
540200
Abstract:
The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from nitrogen deprotected 4-furanylazetidin-2-ones.
Stereoselective Synthesis Of A Chiral Cis 3-Beta Hydrogen (3R) 4-Aroyloxy Azetidinone
David M. Tschaen - Aberdeen NJ Joseph E. Lynch - Plainfield NJ William L. Laswell - Bridgewater NJ Ralph P. Volante - East Windsor NJ Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07B 3710 C07D20508 C07F 718
US Classification:
540200
Abstract:
A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.
Process For The Preparation Of 4-Acyloxyazetidin-2-One By Singlet Oxygen Oxidation
Joseph E. Lynch - Plainfield NJ William L. Laswell - Perkasie PA Ralph P. Volante - East Windsor NJ Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
B01J 1908 C07D20502 C07D20506
US Classification:
20415771
Abstract:
The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by singlet oxygen oxidation.
Oxidation And Reduction Method To Produce 4-Acyloxyazetidin-2-One
Joseph E. Lynch - Plainfield NJ William L. Laswell - Perkasie PA Ralph P. Volante - East Windsor NJ Ichiro Shinkai - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D28510 C07D50134 C07D30756
US Classification:
540200
Abstract:
The 4-acyloxyazetidin-2-ones, which are intermediates in the production of carbapenems and penems, are produced from 4-furanylazetidin-2-ones by a sequential oxidation-reduction-oxidation reaction scheme.