US Patent:
20130317018, Nov 28, 2013
Inventors:
Benjamin David Philpot - Durham NC, US
Mark John Zylka - Chapel Hill NC, US
Bryan Leo Roth - Durham NC, US
John Arthur Allen - North Billerica MA, US
Hsien-Sung Huang - Kaohsiung, TW
International Classification:
C12N 15/63
A61K 31/7048
A61K 31/496
A61K 31/473
A61K 31/4745
A61K 31/4741
US Classification:
5142328, 435375, 514283, 514280, 51425211, 514297, 514 27
Abstract:
The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.