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Arthur C Switchenko

from Sunnyvale, CA
Age ~65

Arthur Switchenko Phones & Addresses

  • 1018 Knickerbocker Dr, Sunnyvale, CA 94087 (408) 749-9329
  • 14 Adin St, Hopedale, MA 01747 (508) 478-0347
  • 16 Hope St, Hopedale, MA 01747
  • San Diego, CA
  • Palo Alto, CA
  • Mountain View, CA

Publications

Us Patents

Method For Detecting Candida Infection

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US Patent:
6426204, Jul 30, 2002
Filed:
Jun 7, 1995
Appl. No.:
08/476394
Inventors:
Charles Garrett Miyada - Mountain View CA
Arthur C. Switchenko - Palo Alto CA
Melanie W Quong - La Jolla CA
Man-Ying Laurie Wong - Fremont CA
Assignee:
Dade Behring Marburg GmbH - Marburg
International Classification:
C12N 904
US Classification:
435190, 435 26, 435 34, 4352554, 435921, 435924
Abstract:
A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. Also disclosed are methods for determining D-arabinitol. In one embodiment the method comprises the steps of providing in combination (1) a medium suspected of containing D-arabinitol and (2) a D-arabinitol dehydrogenase enzyme and examining the medium for the product of the oxidation of the D-arabinitol. The enzyme utilized is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol. Kits for conducting the present method are also disclosed.

Kit Containing D-Arabinitol Dehydrogenase And Nad+ For Determining D-Arabinitol

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US Patent:
57668744, Jun 16, 1998
Filed:
Jun 7, 1995
Appl. No.:
8/479069
Inventors:
Charles Garrett Miyada - Mountainview CA
Arthur C. Switchenko - Palo Alto CA
Melanie W. Quong - La Jolla CA
Man-Ying Laurie Wong - Fremont CA
Assignee:
Syntex (USA) Inc. - San Jose CA
International Classification:
C12Q 132
C12N 904
C12N 116
US Classification:
435 26
Abstract:
A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. The enzyme is preferably obtained from Candida tropicalis ATCC 750 or Candida shehatae. The enzyme may also be obtained by recombinant DNA technology. Monoclonal antibodies are produced against the enzyme and can be used to identify the enzyme. The enzyme is used for detecting the presence of Candida in a host such as detecting Candida infection in a patient by determining the presence of D-arabinitol in a sample. The oxidation of D-arabinitol by nicotinamide adenine dinucleotide (NAD. sup. +) is catalyzed by the enzyme and the amount of NADH produced in a given time is determined. Also prepared is a composition containing the enzyme and NAD. sup.

Compositions And Methods For Removal Of Detergents

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US Patent:
56706901, Sep 23, 1997
Filed:
May 31, 1995
Appl. No.:
8/455920
Inventors:
Arthur C. Switchenko - Palo Alto CA
Nurith Kurn - Palo Alto CA
Christian Neukom - Mountain View CA
Marcel Pirio - San Jose CA
Donald E. Berger - San Jose CA
Edwin F. Ullman - Atherton CA
Assignee:
Behringwerke AG - Marburg
International Classification:
C07C30504
US Classification:
558 31
Abstract:
Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for example, as solubilizing agents for microbial antigens and/or antibodies and for reversibly wetting hydrophobic surfaces. Accordingly, methods are disclosed for increasing the hydrophilic properties of a material, such as a microbial antigen and/or antibody, the methods generally comprising the steps of contacting the material with the compound having detergent properties and a modifiable group, and modifying the compound with a modifying reagent. Kits are also disclosed for use in accordance with this methodology.

Assay By Enzyme-Catalyzed Isotopic Exchange

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US Patent:
52720543, Dec 21, 1993
Filed:
Mar 26, 1992
Appl. No.:
7/857883
Inventors:
Arthur C. Switchenko - Sunnyvale CA
Edwin F. Ullman - Atherton CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C12Q 100
G01N 33567
US Classification:
435 4
Abstract:
A method of assay for isotopically exchangeable analytes is disclosed. Analytes are labeled by enzymatic exchange of a hydrogen atom of the analyte and a deuterium or tritium atom. Preferably, analytes are labeled by reaction with an oxidant, a reducing agent which contains a deuterium or tritium atom, and an enzyme capable of catalyzing the reversible exchange of a hydrogen atom between the analyte, the oxidant, and the reducing agent. Kits for conveniently performing the assay methods are also disclosed.

Method For Detecting Candida Infection

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US Patent:
62809881, Aug 28, 2001
Filed:
Jun 7, 1995
Appl. No.:
8/487946
Inventors:
Charles Garrett Miyada - Mountain View CA
Arthur C. Switchenko - Palo Alto CA
Melanie W Quong - La Jolla CA
Man-Ying Laurie Wong - Fremont CA
Assignee:
Dade Behring Marburg GmbH - Marburg
International Classification:
C12N 904
US Classification:
435190
Abstract:
A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. Also disclosed are methods for determining D-arabinitol. In one embodiment the method comprises the steps of providing in combination (1) a medium suspected of containing D-arabinitol and (2) a D-arabinitol dehydrogenase enzyme and examining the medium for the product of the oxidation of the D-arabinitol. The enzyme utilized is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol. Kits for conducting the present method are also disclosed.

D-Arabinitol Dehydrogenase From Candida Tropicalis Atcc 750 Or Candida Shehatae

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US Patent:
54515173, Sep 19, 1995
Filed:
Mar 3, 1995
Appl. No.:
8/400417
Inventors:
Charles G. Miyada - Mountain View CA
Arthur C. Switchenko - Palo Alto CA
Melanie W. Quong - La Jolla CA
Man-Ying L. Wong - Fremont CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C12N 904
C12N 116
C12N 100
US Classification:
435190
Abstract:
A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is substantially free of other enzymes capable of oxidizing D-mannitol. Also disclosed are methods for determining D-arabinitol. In one embodiment the method comprises the steps of providing in combination (1) a medium suspected of containing D-arabinitol and (2) a D-arabinitol dehydrogenase enzyme and examining the medium for the product of the oxidation of the D-arabinitol. The enzyme utilized is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol. Kits for conducting the present method are also disclosed. The D-arabinitol dehydrogenase in purified form has all of the characteristics of a D-arabinitol dehydrogenase which is obtainable from Candida tropicalis ATCC 750 or Candida shehatae.

Methods For Removal Of Detergents From Analytes

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US Patent:
51167263, May 26, 1992
Filed:
Jul 25, 1988
Appl. No.:
7/223501
Inventors:
Arthur C. Switchenko - Mountain View CA
Nurith Kurn - Palo Alto CA
Christian Neukom - Mountain View CA
Marcel Pirio - San Jose CA
Donald E. Berger - San Jose CA
Edwin F. Ullman - Atherton CA
Assignee:
Syntex (U.S.A.) Inc. - Palo Alto CA
International Classification:
C12Q 170
US Classification:
435 5
Abstract:
Compounds having detergent properties are disclosed. When a modifying reagent is brought into contact with these compounds, the detergent properties are decreased. These compounds are useful, for example, as solubilizing agents for microbial antigens and/or antibodies and for reversibly wetting hydrophobic surfaces. Accordingly, methods are disclosed for increasing the hydrophilic properties of a material, such as a microbial antigen and/or antibody, the methods generally comprising the steps of contacting the material with the compound having detergent properties and a modifiable group, and modifying the compound with a modifying reagent. Kits are also disclosed for use in accordance with this methodology.

Method And Kits For Determining Peroxidatively Active Catalysts

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US Patent:
55321380, Jul 2, 1996
Filed:
Jun 21, 1994
Appl. No.:
8/263164
Inventors:
Sharat Singh - San Jose CA
Arthur C. Switchenko - Palo Alto CA
Cheng-I Lin - Cupertino CA
Nurith Kurn - Palo Alto CA
Edwin F. Ullman - Atherton CA
Assignee:
Behringwerke AG - Marburg
International Classification:
G01N 33546
C12Q 128
US Classification:
435 793
Abstract:
Methods and compositions are disclosed for determining a peroxidatively active catalyst. The methods comprise the step of detecting a substance formed by the coupling reaction of (a) the product of the peroxidatively active catalyst-catalyzed oxidation of a benzidine with (b) a coupler other than benzidine. The methods have application in a wide variety of systems including assays for analytes. Also disclosed are kits for conducting methods and assays in accordance with the present invention.
Arthur C Switchenko from Sunnyvale, CA, age ~65 Get Report