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Arthur R Mcfadden

from Somerset, NJ
Age ~82

Arthur Mcfadden Phones & Addresses

  • Somerset, NJ
  • 212 Chelsa Ct, Bowling Green, KY 42101 (270) 535-9180
  • 810 Champion Dr, Franklin, KY 42134 (270) 598-0377
  • 10 University Rd, East Brunswick, NJ 08816

Publications

Us Patents

Process For Preparing Heteroarylbenzoxepin-Acetic Acids, Precursors And Derivatives Thereof

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US Patent:
41071778, Aug 15, 1978
Filed:
Apr 19, 1977
Appl. No.:
5/788958
Inventors:
Arthur Raymond McFadden - East Brunswick NJ
Daniel Eugene Aultz - Middlesex NJ
Assignee:
American Hoechst Corporation - Bridgewater NJ
International Classification:
C07D33324
US Classification:
2603322C
Abstract:
Heteroarylbenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Analgesic 4-Carboxy-Pyrrolidin-2-One Compound

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US Patent:
44763115, Oct 9, 1984
Filed:
Feb 19, 1982
Appl. No.:
6/349992
Inventors:
Bola V. Shetty - Stamford CT
Arthur McFadden - East Brunswick NJ
Peter Hofer - Liestel, CH
Assignee:
The Purdue Frederick Company - New York NY
International Classification:
A61K 3140
C07D207277
US Classification:
548531
Abstract:
Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR. sub. 5, --CH. sub. 2 CO. sub. 2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl; R. sub. 5 =lower alkyl; R. sub. 1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle; R. sub. 2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl; R. sub. 3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle; R. sub. 2 and R. sub. 3 together form a ring; R. sub. 4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R. sub. 1 and R. sub.

Analgesic And Anti-Inflammatory Compounds

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US Patent:
46395296, Jan 27, 1987
Filed:
Jun 18, 1984
Appl. No.:
6/621680
Inventors:
Bola V. Shetty - Stamford CT
Arthur McFadden - East Brunswick NJ
Peter Hofer - Liestel, CH
Assignee:
The Purdue Frederick Company - Norwalk CT
International Classification:
C07D20712
US Classification:
548550
Abstract:
Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR. sub. 5, --CH. sub. 2 CO. sub. 2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl; R. sub. 5 =lower alkyl; R. sub. 1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle; R. sub. 2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl; R. sub. 3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle; R. sub. 2 and R. sub. 3 together form a ring; R. sub. 4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R. sub. 1 and R. sub.

1-Substituted, 2,3-Diphenyl-3-Hydroxymethyl Pyrrolidines, Where The 2- And/Or 3-Phenyl Can Be Substituted

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US Patent:
47314575, Mar 15, 1988
Filed:
May 27, 1986
Appl. No.:
6/867038
Inventors:
Bola V. Shetty - Stamford CT
Arthur McFadden - East Brunswick NJ
Peter Hofer - Liestel, CH
Assignee:
The Purdue Frederick Company - New York NY
International Classification:
C07D20708
US Classification:
548570
Abstract:
Analgesic and anti-inflamatory compounds of the formula ##STR1## wherein n=0-1, X=Halo, lower Alkoxy, HO--, Lower Alkyl, and R= ##STR2##.

Precursors Of Heterothienobenzoxepin Acetic Acids

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US Patent:
40814572, Mar 28, 1978
Filed:
Apr 19, 1977
Appl. No.:
5/788753
Inventors:
Arthur Raymond McFadden - East Brunswick NJ
Daniel Eugene Aultz - Middlesex NJ
Assignee:
American Hoechst Corporation - Bridgewater NJ
International Classification:
C07D33324
A01N 900
US Classification:
2603322C
Abstract:
Heteroarylbenzoxepin-acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Oxopyridobenzoxepin-Acetic Acids And Derivatives Thereof Useful As Antiinflammatory And Analgesic Agents

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US Patent:
41247132, Nov 7, 1978
Filed:
Apr 19, 1977
Appl. No.:
5/788782
Inventors:
Arthur R. McFadden - East Brunswick NJ
Daniel E. Aultz - Middlesex NJ
Assignee:
American Hoechst Corporation - Bridgewater NJ
International Classification:
A61K 31435
C07D49104
US Classification:
424256
Abstract:
Oxopyridobenzoxepin acetic acids, esters thereof, novel precursors thereof, pharmaceutically acceptable salts thereof and processes for their preparation are disclosed. These compounds are useful as antiinflammatory and analgesic agents.

Preparation Of 6,11-Dihydro-11-Oxodibenz[B,E]-Oxepin-2-Acetic Acid And Precursors Therefor

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US Patent:
41752090, Nov 20, 1979
Filed:
Sep 5, 1978
Appl. No.:
5/939111
Inventors:
Arthur R. McFadden - East Brunswick NJ
Richard C. Allen - Flemington NJ
Thomas B. K. Lee - Whitehouse Station NJ
Assignee:
American Hoechst Corporation - Bridgewater NJ
International Classification:
C07C 6359
US Classification:
562473
Abstract:
A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.

Dihydro-Dibenzoxepines-Thiepines And -Morphanthridones, Compositions And Use

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US Patent:
43351220, Jun 15, 1982
Filed:
Mar 18, 1981
Appl. No.:
6/225122
Inventors:
Arthur R. McFadden - East Brunswick NJ
Daniel E. Aultz - Middlesex NJ
Assignee:
Hoechst-Roussel Pharmaceuticals Inc. - Somerville NJ
International Classification:
A61K 31335
A61K 3155
C07D22320
C07D31312
US Classification:
424244
Abstract:
The invention relates to diuretic dihydro-dibenzoxepines-thiepines and -morphanthridones of the formula ##STR1## wherein R is ##STR2## where R. sup. 4 is a hydrogen or an alkyl; R. sup. 1 is hydrogen or alkyl; R. sup. 2 and R. sup. 3 are the same or different and are hydrogen, alkyl or R. sup. 2 and R. sup. 3 are fused to form a pyrrolidino, morpholino, piperidino or azepino ring substituent; Y is hydrogen, halogen and alkoxy, X is ##STR3## where R. sup. 4 is as defined above; m is an integer of 0 or 1; and n is an integer of 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.
Arthur R Mcfadden from Somerset, NJ, age ~82 Get Report