Inventors:
Bola V. Shetty - Stamford CT
Arthur McFadden - East Brunswick NJ
Peter Hofer - Liestel, CH
Assignee:
The Purdue Frederick Company - New York NY
International Classification:
A61K 3140
C07D207277
Abstract:
Analgesic and anti-inflammatory compounds are provided. These compounds possess the following general formula: ##STR1## wherein R=--COOR. sub. 5, --CH. sub. 2 CO. sub. 2 H, ##STR2## wherein A and B=hydrogen, lower alkyl, hydroxy alkyl, lower alkyl amine, substituted lower alkyl amine, aminoalkyl, substituted aminoalkyl; R. sub. 5 =lower alkyl; R. sub. 1 =aryl, substituted aryl, aralkyl, alkyl, hydrogen, substituted aralkyl and heterocycle; R. sub. 2 =aryl, substituted aryl, aralkyl, alkyl, substituted aralkyl, heterocycle, substituted heterocycle, biphenyl, substituted biphenyl, naphthyl, and substituted naphthyl; R. sub. 3 =aryl, substituted aryl, hydrogen, aralkyl, substituted aralkyl, alkyl, heterocycle and substituted heterocycle; R. sub. 2 and R. sub. 3 together form a ring; R. sub. 4 =hydrogen, phenyl, substituted phenyl, heterocycle; alkyl, substituted alkyl; or, R. sub. 1 and R. sub.