US Patent:
20040235931, Nov 25, 2004
Inventors:
John Docherty - Kent OH, US
Angelo DeLucia - Kent OH, US
International Classification:
C12Q001/70
A61K031/405
Abstract:
The present invention provides a method of inhibiting the formation of infectious herpes virus particles, particularly infectious herpes simplex virus (HSV) particles, in a host cell. The method involves administering an effective amount of indole-3-carbinol to a herpes virus infected host cell. The present invention also provides a method of treating a herpes virus infection, particularly an HSV infection. The method comprises administering a topical composition comprising a therapeutically effective amount of I3C or a pharmaceutically acceptable salt or ester thereof to a herpes virus-infected site. The present invention also relates to a topical composition for treating a herpes virus infection selected from the group consisting of an HSV infection, a cytomegalovirus infection, and a varicella zoster virus infection.