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Alexandre L Zanghellini

from Ithaca, NY
Age ~47
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Connected to:
Jessica E Zanghi, 39Josephine Zanghi, 96Lauren Zanghi, 72Lawrence P Zanghi, 81Ali A Zangi, 51Uzi Zangi, 58Julie Zangl, 69Lauren E Zangl, 39Muriel I Zangl, 96Maria Zangla, 101

Alexandre Zanghellini Phones & Addresses

  • Ithaca, NY
  • Berkeley, CA
  • 5527 15Th St, Seattle, WA 98105 (206) 729-5802

Publications

Us Patents

Synthetic Enzymes Derived From Computational Design

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US Patent:
20090191607, Jul 30, 2009
Filed:
Dec 12, 2008
Appl. No.:
12/334360
Inventors:
David Baker - Seattle WA, US
Alexandre Zanghellini - Seattle WA, US
Lin Jiang - Seattle WA, US
Andrew Wollacott - Cambridge MA, US
Eric Althoff - Seattle WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
C12N 9/14
US Classification:
435195
Abstract:
Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.

Synthetic Enzymes Derived From Computational Design

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US Patent:
20120142077, Jun 7, 2012
Filed:
Dec 1, 2011
Appl. No.:
13/308699
Inventors:
David Baker - Seattle WA, US
Alexandre Zanghellini - Seattle WA, US
Lin Jiang - Seattle WA, US
Andrew Wollacott - Cambridge MA, US
Eric Althoff - Seattle WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
C12N 9/88
C12N 9/00
US Classification:
435232, 435183
Abstract:
Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.

Fermentation Route For The Production Of Levulinic Acid, Levulinate Esters And Valerolactone And Derivatives Thereof

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US Patent:
20130330779, Dec 12, 2013
Filed:
Aug 30, 2011
Appl. No.:
13/820028
Inventors:
Alexandre Luc Zanghellini - Seattle WA, US
International Classification:
C12P 17/04
C12P 7/62
C12P 7/42
C12P 7/40
US Classification:
435 92, 435136, 435135, 435146, 435126, 435158, 435106, 435132, 435167
Abstract:
The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.

Mutant Polypeptides And Uses Thereof

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US Patent:
20190300871, Oct 3, 2019
Filed:
Jan 2, 2019
Appl. No.:
16/237871
Inventors:
- Wilmington DE, US
Nadia KADI - Marton, GB
Mihai AZOITEI - Chapel Hill NC, US
Alexander PISARCHIK - Bothell WA, US
Alexandre ZANGHELLINI - Seattle WA, US
Adriana L. BOTES - Rosedale East - Cleveland, GB
Assignee:
INVISTA North America S.à.r.l. - Wilmington DE
International Classification:
C12N 9/88
A61K 38/00
C12P 5/00
C07C 11/21
C12P 5/02
C08F 136/06
C07C 11/167
C07C 11/18
G01N 33/573
C07K 16/40
C08F 36/06
C08F 36/08
C08F 36/22
C08F 136/08
Abstract:
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

Mutant Polypeptides And Uses Thereof

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US Patent:
20180030431, Feb 1, 2018
Filed:
May 12, 2017
Appl. No.:
15/593395
Inventors:
- Wilmington DE, US
Nadia KADI - Marton, GB
Mihai Luchian AZOITEI - Chapel Hill NC, US
Alexander PISARCHIK - Bothell WA, US
Alexandre ZANGHELLINI - Seattle WA, US
Adriana L. BOTES - Rosedale East - Cleveland, UK
Assignee:
INVISTA North America S.A.R.L. - Wilmington DE
International Classification:
C12N 9/88
C08F 136/06
C07C 11/167
C07C 11/18
C07C 11/21
C07K 16/40
C12P 5/00
C08F 136/08
A61K 38/00
C08F 36/22
C08F 36/08
C08F 36/06
G01N 33/573
C12P 5/02
Abstract:
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

Fermentation Route For The Production Of Levulinic Acid, Levulinate Esters And Valerolactone And Derivatives Thereof

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US Patent:
20170275657, Sep 28, 2017
Filed:
Nov 9, 2016
Appl. No.:
15/347346
Inventors:
- Seattle WA, US
Alexandre Luc ZANGHELLINI - Seattle WA, US
International Classification:
C12P 7/62
C12P 7/40
C12P 17/04
C12P 7/42
Abstract:
The invention provides processes for the conversion of pyruvate obtained from sugars or other carbon sources, to valuable C5 materials such as levulinic acid, levulinate esters, valerolactone, and derivatives thereof.

Mutant Polypeptides And Uses Thereof

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US Patent:
20160304852, Oct 20, 2016
Filed:
Aug 24, 2015
Appl. No.:
14/833206
Inventors:
- Wilmington DE, US
Nadia Kadi - Marton, GB
Mihai Luchian Azoitei - Chapel Hill NC, US
Alexander Pisarchik - Bothell WA, US
Alexandre Zanghellini - Seattle WA, US
Eric Althoff - Seattle WA, US
Assignee:
INVISTA S.a.r.l. - Wilmington DE
International Classification:
C12N 9/88
C07C 11/167
C07C 11/18
C08F 136/08
C08F 136/06
Abstract:
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.

Mutant Polypeptides And Uses Thereof

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US Patent:
20160251645, Sep 1, 2016
Filed:
Feb 29, 2016
Appl. No.:
15/056026
Inventors:
- Wilmington DE, US
Nadia Kadi - Marton, GB
Mihai Luchian Azoitei - Chapel Hill NC, US
Alexander Pisarchik - Bothell WA, US
Alexandre Zanghellini - Seattle WA, US
Eric Althoff - Seattle WA, US
Assignee:
INVISTA North America S.a.r.l. - Wilmington DE
International Classification:
C12N 9/88
C07K 16/40
G01N 33/573
C12P 5/00
C08F 36/06
C07C 11/18
C07C 11/21
C08F 36/08
C08F 36/22
C12P 5/02
C07C 11/167
Abstract:
The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.
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Alexandre L Zanghellini from Ithaca, NY, age ~47 Get Report