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Alexander L Watters

from Melrose, MA
Age ~50
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Also known as:
Alexander L Wattes, Alex Watters
Related to:
Michael Barrett Martin, 52
Connected to:
Ashlee M Watterson, 30Ashlie D Watters, 40Autumn L Watters, 42Barry A Watters, 61Beth A Watters, 73Beverly M Watters, 90Blake A Watters, 30Brandon M Watterson, 42Caitlin M Watters, 37Cassie Watters, 39

Alexander Watters Phones & Addresses

  • Melrose, MA
  • San Francisco, CA
  • 4100 Densmore Ave, Seattle, WA 98103 (206) 632-6089
  • 4122 Whitman Ave, Seattle, WA 98103 (206) 632-6089 (206) 632-7770
  • 279 Sutton St, North Andover, MA 01845 (978) 794-7873
  • Hopkins, MN
  • Northfield, MN
  • Minneapolis, MN
  • 1615 N 40Th St, Seattle, WA 98103

Work

Company: Wyss institute for biologically inspired engineering Jan 2015 Position: Senior staff scientist

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Washington 1998 to 2005 Specialities: Biology

Skills

Protein Chemistry • Cell Culture • Molecular Biology • Protein Expression • Biochemistry • Assay Development • Microscopy • Elisa • Protein Engineering • Cell Biology • Cell • Biophysics • Purification • Fluorescence • Bioinformatics • Electrophoresis

Industries

Biotechnology

Resumes

Resumes

Alexander Watters Photo 1

Research Principal Scientist

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Location:
343 Washington St, San Francisco, CA 94111
Industry:
Biotechnology
Work:
Wyss Institute For Biologically Inspired Engineering
Senior Staff Scientist
Wyss Institute For Biologically Inspired Engineering Nov 2010 - Dec 2014
Staff Scientist
Amgen Dec 2008 - Jul 2010
Scientist
Ucsf Jan 2006 - Dec 2008
Postdoctoral Scholar
University of Washington Oct 1998 - Jun 2005
Research Assistant
Education:
University of Washington 1998 - 2005
Doctorates, Doctor of Philosophy, Biology Carleton College 1992 - 1996
Bachelors, Bachelor of Arts, Bachelor of Arts In Business Administration, Biology University of Louisville
Wyss Institute For Biologically Inspired Engineering
Skills:
Protein Chemistry
Cell Culture
Molecular Biology
Protein Expression
Biochemistry
Assay Development
Microscopy
Elisa
Protein Engineering
Cell Biology
Cell
Biophysics
Purification
Fluorescence
Bioinformatics
Electrophoresis

Publications

Us Patents

Pathogen Binding Methods And Compositions

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US Patent:
20220195017, Jun 23, 2022
Filed:
Dec 30, 2021
Appl. No.:
17/565783
Inventors:
- Cambridge MA, US
Michael Super - Lexington MA, US
Alexander L. Watters - North Andover MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C07K 16/12
G01N 33/487
A61P 31/04
G01N 33/543
G01N 33/569
C07K 16/14
C07K 14/705
Abstract:
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.

Methods For Capturing, Isolation, And Targeting Of Circulating Tumor Cells And Diagnostic And Therapeutic Applications Thereof

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US Patent:
20210364522, Nov 25, 2021
Filed:
Aug 4, 2021
Appl. No.:
17/393892
Inventors:
- Cambridge MA, US
Donald E. INGBER - Boston MA, US
Michael SUPER - Lexington MA, US
Alexander L. WATTERS - North Andover MA, US
Harry Scott DRISCOLL - Allston MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
G01N 33/574
A61K 47/64
A61K 39/00
Abstract:
The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

Engineered Microbe-Targeting Molecules And Uses Thereof

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US Patent:
20210155677, May 27, 2021
Filed:
Nov 10, 2020
Appl. No.:
17/093781
Inventors:
- Cambridge MA, US
Michael SUPER - Lexington MA, US
Jeffrey Charles WAY - Cambridge MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Julia B. BERTHET - Brookline MA, US
Dinah R. SUPER - Lexington MA, US
Martin ROTTMAN - St. Cloud, FR
Alexander L. WATTERS - Melrose MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
C07K 16/12
A61K 47/68
G01N 33/543
G01N 33/569
C07K 14/42
Abstract:
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

Engineered Heme-Binding Compositions And Uses Thereof

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US Patent:
20200248158, Aug 6, 2020
Filed:
Oct 23, 2019
Appl. No.:
16/661595
Inventors:
- Cambridge MA, US
Alexander L. WATTERS - North Andover MA, US
Philip T. SNELL - Lexington MA, US
Donald E. INGBER - Boston MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
C12N 9/26
C12N 9/96
C07K 14/805
A61K 38/00
Abstract:
Described herein are heme-binding compositions and methods relating to their use, for example methods of treatment of sepsis and rhabdomyolysis.

Engineered Microbe-Targeting Molecules And Uses Thereof

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US Patent:
20200239552, Jul 30, 2020
Filed:
Nov 14, 2019
Appl. No.:
16/683630
Inventors:
- Cambridge MA, US
Michael SUPER - Lexington MA, US
Jeffrey Charles WAY - Cambridge MA, US
Mark J. CARTWRIGHT - West Newton MA, US
Julia B. BERTHET - Brookline MA, US
Dinah R. SUPER - Lexington MA, US
Martin ROTTMAN - St. Cloud, FR
Alexander L. WATTERS - Melrose MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
C07K 16/12
A61K 47/68
G01N 33/543
G01N 33/569
C07K 14/42
Abstract:
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

Aqueous Biomolecule Coupling On Co2-Plasma-Activated Surfaces

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US Patent:
20190144567, May 16, 2019
Filed:
May 16, 2017
Appl. No.:
16/302023
Inventors:
- Cambridge MA, US
Thomas DOYLE - Boston MA, US
Anna WATERHOUSE - Brookline MA, US
Melissa RODAS - Boston MA, US
Alexander L. WATTERS - North Andover MA, US
Michael SUPER - Lexington MA, US
Donald E. INGBER - Boston MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
C07K 17/08
C08L 25/06
C08L 83/04
G01N 33/545
G01N 33/543
Abstract:
This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.

Methods For Capturing, Isolation, And Targeting Of Circulating Tumor Cells And Diagnostic And Therapeutic Applications Thereof

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US Patent:
20190145980, May 16, 2019
Filed:
Apr 10, 2017
Appl. No.:
16/092288
Inventors:
- Cambridge MA, US
Donald INGBER - Boston MA, US
Michael SUPER - Lexington MA, US
Alexander WATTERS - North Andover MA, US
Harry DRISCOLL - Allston MA, US
Assignee:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
International Classification:
G01N 33/574
A61K 39/00
A61K 47/64
Abstract:
The invention relates to methods of detection, capture, isolation and targeting of cancer cells for example circulating tumor cells (CTCs) using carbohydrate recognition domain of a lectin. The invention relates to methods of diagnosis, prognosis and treatment of cancer.

Pathogen Binding Methods And Compositions

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US Patent:
20190077850, Mar 14, 2019
Filed:
Aug 9, 2018
Appl. No.:
16/059799
Inventors:
- Cambridge MA, US
Michael Super - Lexington MA, US
Alexander Watters - North Andover MA, US
International Classification:
C07K 16/12
G01N 33/487
G01N 33/569
G01N 33/543
A61P 31/04
Abstract:
Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.
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Alexander L Watters from Melrose, MA, age ~50 Get Report