Inventors:
Harold C. Box - Williamsville NY
Alexander E. Maccubbin - Kenmore NY
Edwin E. Budzinski - West Seneca NY
Herbert Iijima - Williamsville NY
Assignee:
Health Research Inc. - Buffalo NY
International Classification:
C12Q 168
C12P 1934
Abstract:
A method is provided for detecting and quantitating a DNA base modification in a sample of DNA, wherein the method involves an endonuclease digestion step, a labeling step, and a chromatographic separation step. Utilized in the method are compositions including a carrier for the DNA base modification, an internal standard, and a carrier for the internal standard. Also provided are methods for synthesizing the compositions, and kits containing the compositions.