US Patent:
20080146645, Jun 19, 2008
Inventors:
Anita Wai-Yin Chan - Fort Lee NJ, US
Zhixian Ding - Fort Lee NJ, US
Mousumi Ghosh - Elmwood Park NJ, US
Mahmut Levent - Bloomfield NJ, US
Panolil Raveendranath - Monroe NY, US
Jianxin Ren - Nanuet NY, US
Maotang Zhou - Cedar Knolls NJ, US
Asaf Alimardanov - Nanuet NY, US
Alexander V. Gontcharov - Rivervale NJ, US
Antonia A. Nikitenko - Tarrytown NY, US
John R. Potoski - West Nyack NY, US
Girija Raveendranath - Monroe NY, US
Vijay Raveendranath - Albany NY, US
Sanjay Raveendranath - Monroe NY, US
International Classification:
C07D 209/34
A61K 31/4015
Abstract:
Processes are disclosed for preparing indolinone phenylaminopropanol derivatives, particularly chiral indolinone phenylaminopropanol derivatives of the general formula:The processes disclosed may be used to prepare, inter alia, 7-fluoro-1-[(S, 2R)-1-(3-fluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one and 7-fluoro-1-[(S, 2R)-1-(3,5-difluorophenyl)-2-hydroxy-3-(methylamino)propyl]-3,3-dimethyl-1,3-dihydro-2H-indol-2-one. Intermediates of the processes are also disclosed.