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Albert Cale Phones & Addresses

  • Mechanicsville, VA
  • Windsor, NC

Publications

Us Patents

4,5-Dihydro-3,3-Diphenyl-4-Hydrocarbylaminomethylfuran-2(3H) Ones

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US Patent:
42960371, Oct 20, 1981
Filed:
Jul 24, 1978
Appl. No.:
6/127001
Inventors:
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07D30726
US Classification:
2603436
Abstract:
1-Hydrocarbon-3,3-diphenyl-4-hydroxymethyl-2-pyrrolidinones and methods for making them from 4,5-dihydro-3,3-diphenyl-4-hydrocarbylaminomethylfuran-2(3H)ones are disclosed. Methods for making the 4,5-dihydro-3,3-diphenyl-4-hydrocarbylaminomethylfuran-2(3H)ones are also disclosed. The novel compounds are useful intermediates for the preparation of pharmacologically active 4-(4,4-disubstitutedpiperidinylmethyl)-3,3-diphenyl-2-pyrrolidinones.

4-Aryl-N-(Alkylaminoalkyl, Heterocyclicamino And Heterocyclicamino)Alkyl)-1-Piperazinecarboxamides

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US Patent:
49607766, Oct 2, 1990
Filed:
Jan 28, 1987
Appl. No.:
7/007592
Inventors:
David A. Walsh - Richmond VA
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Inc. - Richmond VA
International Classification:
A61K 31495
A61K 31445
C07D40112
C07D40312
US Classification:
514252
Abstract:
Novel 4-aryl-N-[2-(dialkylamino and heterocyclicamino)alkyl]-1-piperazinecarboxamides of the formula: ##STR1## wherein B is oxygen or sulfur; Ar is selected from ##STR2## or 2, 3 or 4-pyridyl; X is selected from hydrogen, halogen, loweralkyl, loweralkoxy, amino, dimethylamino, nitro, trifluoromethyl, cyano, acetyl, acetylamino, aminocarbonyl, carboxy or loweralkylcarboxylic acid ester; Y is selected from hydrogen, halogen, loweralkyl, loweralkoxy, nitro, trifluoromethyl, cyano, acetylamino, aminocarbonyl, carboxy or loweralkyl carboxylic acid ester; Z is selected from hydrogen, loweralkyl or loweralkoxy; Q is selected from ##STR3## m is 1 to 3 inclusive; n is zero or 1; p is zero to 3 inclusive; R. sup. 1, R. sup. 2 and R. sup. 3 are loweralkyl and may be the same or different, or R. sup. 1 and R. sup. 2 taken together with the adjacent nitrogen atom may be form a heterocyclic residue; and the pharmaceutically acceptable salts thereof are disclosed.

Method For Controlling Emesis With N-(1-Substituted-3-Pyrrolidinyl)Benzamides And Thiobenzamides

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US Patent:
39669572, Jun 29, 1976
Filed:
Oct 25, 1974
Appl. No.:
5/518123
Inventors:
Albert Duncan Cale - Mechanicsville VA
Charles Arthur Leonard - Richmond VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
A61K 3140
US Classification:
424274
Abstract:
A method is disclosed for controlling emesis utilizing N-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides of the formula: ##SPC1## Wherein R is cycloalkyl, phenyl and phenyllower-alkyl; R. sup. 1 is hydrogen, lower alkyl of 1 to 8 carbon atoms and phenyl; R. sup. 2 is halogen, lower-alkyl, lower-alkoxy, amino, nitro, monoalkylamino, dialkylamino, mercaptomethyl, acetamido, sulfamoyl, cyano, hydroxy, benzyloxy, and trifluoromethyl; X is oxygen and sulfur; n is an integer from zero to three inclusive and pharmaceutically acceptable acid addition salts thereof. The benzamide compounds wherein R is cyclohexyl and R. sup. 1 is lower-alkyl are particularly effective as antiemetics and have minimal side effects.

Chemical Intermediates In The Preparation Of Aromatic-1,4-Oxazepinones And Thiones

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US Patent:
47835354, Nov 8, 1988
Filed:
Mar 18, 1986
Appl. No.:
6/840811
Inventors:
Young S. Lo - Richmond VA
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07D21380
C07D21382
C07D23112
C07D23306
US Classification:
546316
Abstract:
A process for the preparation of 1,4-oxazepinones and thiones having the formula: ##STR1## wherein A is an aromatic ring selected from benzene, naphthalene, quinoline or pyridine; n is 1 to 3; Z is an amino radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; and R. sup. 4 and R. sup. 5 are hydrogen and loweralkyl starting from chloroaromatic carboxylates and alkanolamines is disclosed. The oxazepinones and oxazepinethiones prepared by the process have utility as antihistaminics with low sedative potential. Novel intermediate compounds are also disclosed.

4-Substituted 2-Iminoimidazolidine Compounds

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US Patent:
42477050, Jan 27, 1981
Filed:
Feb 6, 1979
Appl. No.:
6/009899
Inventors:
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Inc. - Richmond VA
International Classification:
C07D23350
C07D23348
C07D23346
US Classification:
548315
Abstract:
This invention provides a novel class of 2-iminoimidazolidines which include 4-substituted derivatives such as 4-(2-chloroethyl)-1-methyl-2-methylimino-3-phenyl imidazolidine fumarate: ##STR1## This illustrated 4-substituted 2-iminoimidazolidine compound exhibits cardiovascular hypotensive, hypoglycemic (glucose tolerance, and sugar cataract) and anti-inflammatory (pleural effusion) pharmacological activities in test animals.

Methods Useful In The Treatment Of Cardiac Arrhythmia Using 4-Substituted-2-Iminoimidazolidine Compounds

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US Patent:
43271081, Apr 27, 1982
Filed:
May 5, 1980
Appl. No.:
6/146612
Inventors:
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Inc. - Richmond VA
International Classification:
A61K 31415
A61K 31495
A61K 31445
US Classification:
424273R
Abstract:
This invention provides a novel class of 2-iminoimidazolidines which include 4-substituted derivatives such as 4-(2-chloroethyl)-1-methyl-2-methylimino-3-phenyl imidazolidine fumarate: ##STR1## This illustrated 4-substituted 2-iminoimidazolidine compound exhibits cardiovascular hypotensive, hypoglycemic (glucose tolerance, and sugar cataract) and anti-inflammatory (pleural effusion) pharmacological activities in test animals.

Fused Aromatic Oxazepinones, Thiazepinones, Diazepinones And Sulfur Analogs Thereof In A Method Of Counteracting Histamine

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US Patent:
46043888, Aug 5, 1986
Filed:
Jul 9, 1985
Appl. No.:
6/753325
Inventors:
Charles A. Leonard - Richmond VA
Bernard V. Franko - Richmond VA
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
A61U 3155
US Classification:
514211
Abstract:
A method of counteracting the effects of histamine with aromatic azepinones and diazepinones and thiones thereof having the formula ##STR1## wherein: A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur: E is oxygen, sulfur or loweralkyl substituted nitrogen; n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing radical; R is hydrogen, loweralkyl, cycloalkyl or phenyl-loweralkyl; and compositions therefor are disclosed.

Fused Aromatic Oxazepinones, Thiazepinones, Diazepinones And Sulfur Analogs Thereof

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US Patent:
48125652, Mar 14, 1989
Filed:
Feb 25, 1987
Appl. No.:
7/018676
Inventors:
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07D22316
US Classification:
540491
Abstract:
This invention is directed to compounds having the formula: ##STR1## wherein: A represents an aromatic or heterocyclic ring having two of its carbon atoms held mutually with the oxazepine, thiazepine or diazepine moiety selected from the group consisting of benzene, naphthalene, a quinoline, a pyridine in any of its four positions, any of which rings are optionally substituted by one or two Y radicals selected from the group consisting of halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, lower acylamino, trilfuoromethyl, phenyl or phenyl substituted by one to three Y' groups selected from halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracylamino or trifluoromethyl, E is selected from oxygen, sulfur or ##STR2## B is selected from the group consisting of loweralkyl, cycloalkyl or phenyl-loweralkyl wherein phenyl is optionally substituted by one or two radicals selected from halo, loweralkyl, loweralkoxy, nitro or trifuoromethyl, N is 1 or 2, R. sup. 4 and R. sup. 5 are selected from hydrogen or loweralkyl (1-5 C), X is halogen selected from chlorine, bromine, cyano or 1-phthalimido, the optical isomers thereof and the acid addition salts thereof. These compounds are valuable intermediates in the preparation of compounds having antihistaminic utility.
Albert D Cale from Mechanicsville, VA, age ~96 Get Report