Inventors:
Albert D. Cale - Mechanicsville VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
C07D22316
Abstract:
This invention is directed to compounds having the formula: ##STR1## wherein: A represents an aromatic or heterocyclic ring having two of its carbon atoms held mutually with the oxazepine, thiazepine or diazepine moiety selected from the group consisting of benzene, naphthalene, a quinoline, a pyridine in any of its four positions, any of which rings are optionally substituted by one or two Y radicals selected from the group consisting of halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, lower acylamino, trilfuoromethyl, phenyl or phenyl substituted by one to three Y' groups selected from halo, loweralkyl, loweralkoxy, diloweralkylamino, nitro, amino, loweracylamino or trifluoromethyl,
E is selected from oxygen, sulfur or ##STR2## B is selected from the group consisting of loweralkyl, cycloalkyl or phenyl-loweralkyl wherein phenyl is optionally substituted by one or two radicals selected from halo, loweralkyl, loweralkoxy, nitro or trifuoromethyl,
N is 1 or 2,
R. sup. 4 and R. sup. 5 are selected from hydrogen or loweralkyl (1-5 C),
X is halogen selected from chlorine, bromine, cyano or 1-phthalimido, the optical isomers thereof and the acid addition salts thereof.
These compounds are valuable intermediates in the preparation of compounds having antihistaminic utility.