Inventors:
Alan C. Sartorelli - Woodbridge CT
Alan A. Divo - Branford CT
Krishnamurthy Shyam - Hamden CT
Philip G. Penketh - New Haven CT
Assignee:
Yale University - New Haven CT
International Classification:
A61K 3118
Abstract:
Sulfonylhydrazines of the formula RSO. sub. 2 N(CH. sub. 2 CH. sub. 2 X)N(SO. sub. 2 CH. sub. 3). sub. 2, wherein R is an alkyl or an aryl and X is a halogen or OSO. sub. 2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydrazines are useful in treating cancer. Methylating agents of the formula (a) R'SO. sub. 2 N(CH. sub. 3)N(SO. sub. 2 CH. sub. 3). sub. 2, wherein R' is an alkyl or an aryl and (b) R"SO. sub. 2 N(CH. sub. 3)N(CH. sub. 3)SO. sub. 2 R", wherein R" is an alkyl or an aryl. Such methylating agents are useful as antitrypanosomal and anticancer agents.