Inventors:
Mark Modell - Natick MA
Zeev Hed - Nashua NH
David Bee - Groton MA
David Lipson - Newton MA
Jennie Kwo - Cambridge MA
Matthew Emans - Boston MA
Robert Nordstrom - Hanover MA
Assignee:
MediSpectra, Inc. - Lexington MA
International Classification:
A61B 505
US Classification:
600407, 600473, 600476, 2504612, 356317
Abstract:
Methods and apparatus are provided for determining a characteristic of a sample of a material by the interaction of electromagnetic radiation with the sample. The apparatus includes an optical assembly and a protective barrier. The optical assembly sequentially illuminates a plurality of volume elements in the sample with an intensity distribution in the sample that drops off substantially monotonically from a first region in a first optical path and collects electromagnetic radiation emanating from each of the volume elements. The optical assembly collects the electromagnetic radiation emanating from each of the volume elements with a collected distribution that drops off substantially monotonically from a second region in a second optical path. The first and second regions at least partially overlap in each of the volume elements. The optical assembly can be configured as a probe, to be directed to the evaluation of a sample of a biological material.