US Patent:
20140235535, Aug 21, 2014
Inventors:
Mary Erickson - San Diego CA, US
David C. Litzinger - San Diego CA, US
Soumitra S. Ghosh - San Diego CA, US
Zijian Guo - San Diego CA, US
Manoj P. Samant - San Diego CA, US
Abhinandini Sharma - San Diego CA, US
Lala Mamedova - San Diego CA, US
Esther Odile Levy - San Diego CA, US
Caroline Ekblad - San Diego CA, US
International Classification:
C07K 14/605
US Classification:
514 53, 530308, 536 234, 514 72, 514 74, 514 117, 4353201, 435325, 435364, 435367, 435360, 4353651, 435352, 435370, 435357, 435350, 435369, 4352542, 435348, 43525233
Abstract:
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration, and reduced immunogenicity. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including obesity and overweight, diabetes, dyslipidemia, hyperlipidemia, Alzheimer's disease, fatty liver disease, Short Bowel Syndrome, Parkinson's disease, and cardiovascular disease.