Aamir Mir Phones & Addresses
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North Grafton, MA
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Medford, MA
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4832 Bernal Ave APT F, Pleasanton, CA 94566
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Worcester, MA
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West Lafayette, IN
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Appleton, WI
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W Lafayette, IN
Publications
Us Patents
Programmable Dna Base Editing By Nme2Cas9-Deaminase Fusion Proteins
View pageUS Patent:
20220290113, Sep 15, 2022
Filed:
Oct 15, 2019
Appl. No.:
17/285440
Inventors:
- Boston MA, US
Xin Gao - Maynard MA, US
Aamir Mir - Pleasanton CA, US
Alireza Edraki - Worcester MA, US
Scot A. Wolfe - Winchester MA, US
Pengpeng Liu - Worcester MA, US
Xin Gao - Maynard MA, US
Aamir Mir - Pleasanton CA, US
Alireza Edraki - Worcester MA, US
Scot A. Wolfe - Winchester MA, US
Pengpeng Liu - Worcester MA, US
International Classification:
C12N 9/22
C12N 9/78
C12N 15/11
C12N 15/62
C12N 15/86
A61P 3/00
C12N 9/78
C12N 15/11
C12N 15/62
C12N 15/86
A61P 3/00
Abstract:
The present invention is related to the field of gene editing. In particular, the gene editing is directed toward single nucleotide base editing. For example, such single nucleotide base editing results in a conversion of a OG base pair to a T*A base pair. The high accuracy and precision of the presently disclosed single nucleotide base gene editor is accomplished by an NmeCas9 nuclease that is fused to a nucleotide deaminase protein. The compact nature of the NmeCas9 coupled with a larger number of compatible protospacer adjacent motifs provide the Cas9 fusion constructs contemplated herein to have a gene editing window that can edit sites that are not targetable by other conventional SpyCas9 base editor platforms.
Modified Guide Rnas For Crispr Genome Editing
View pageUS Patent:
20210363518, Nov 25, 2021
Filed:
Mar 18, 2019
Appl. No.:
16/981908
Inventors:
- Boston MA, US
Anastasia KHVOROVA - Westborough MA, US
Jonathan Kenneth WATTS - Worcester MA, US
Aamir MIR - Worcester MA, US
Julia Frances ALTERMAN - Worcester MA, US
Matthew Ryan HASSLER - Worcester MA, US
Michael Harry BRODSKY - Sudbury MA, US
Alexandre Jean-Marie DEBACKER - Worcester MA, US
Anastasia KHVOROVA - Westborough MA, US
Jonathan Kenneth WATTS - Worcester MA, US
Aamir MIR - Worcester MA, US
Julia Frances ALTERMAN - Worcester MA, US
Matthew Ryan HASSLER - Worcester MA, US
Michael Harry BRODSKY - Sudbury MA, US
Alexandre Jean-Marie DEBACKER - Worcester MA, US
International Classification:
C12N 15/11
C12N 9/22
C12N 15/90
C12N 9/22
C12N 15/90
Abstract:
Chemically modified crRNAs and tracrRNAs are provided. crRNAs and tracrRNAs with 5′ and/or 3′ conjugated moieties are provided. crRNAs and tracrRNAs with modifications in the repeat region of the crRNA or the anti-repeat region of the tracrRNA are provided. Methods of using the crRNAs and tracrRNAs for genome editing with a CRISPR nuclease and kits for performing the same are also provided.
Compositions And Methods For Improved Gene Editing
View pageUS Patent:
20190345479, Nov 14, 2019
Filed:
Apr 15, 2019
Appl. No.:
16/384612
Inventors:
- Boston MA, US
Krishna Sumanth Ghanta - Grafton MA, US
Gregoriy Dokshin - Belmont MA, US
Aamir Mir - Worcester MA, US
Jonathan Kenneth Watts - Worcester MA, US
Erik Joseph Sontheimer - Auburndale MA, US
Krishna Sumanth Ghanta - Grafton MA, US
Gregoriy Dokshin - Belmont MA, US
Aamir Mir - Worcester MA, US
Jonathan Kenneth Watts - Worcester MA, US
Erik Joseph Sontheimer - Auburndale MA, US
International Classification:
C12N 15/10
C12N 15/113
C12N 15/66
C12N 9/22
C12N 15/113
C12N 15/66
C12N 9/22
Abstract:
The disclosure provides novel methods and compositions for gene editing. In particular, the disclosure relates to compositions and methods of making modified nucleic acid donor templates for highly efficient and precise gene editing.
Targeted Crispr Delivery Platforms
View pageUS Patent:
20190338308, Nov 7, 2019
Filed:
Nov 9, 2018
Appl. No.:
16/186352
Inventors:
- Boston MA, US
Raed Ibraheim - Shrewsbury MA, US
Wen Xue - Natick MA, US
Aamir Mir - Worcester MA, US
Alireza Edraki - Worcester MA, US
Ildar Gainetdinov - Worcester MA, US
Raed Ibraheim - Shrewsbury MA, US
Wen Xue - Natick MA, US
Aamir Mir - Worcester MA, US
Alireza Edraki - Worcester MA, US
Ildar Gainetdinov - Worcester MA, US
International Classification:
C12N 15/86
C12N 15/11
A61K 48/00
C12N 15/11
A61K 48/00
Abstract:
The present invention is related to compositions and methods for gene therapy. Several approaches described herein utilize the Cas9 system that provides a hyperaccurate CRISPR gene editing platform. Furthermore, the invention incorporates full length and truncated single guide RNA sequences that permit a complete sgRNA-Nme1Cas9 vector to be inserted into an adeno-associated viral plasmid that is compatible for in vivo administration. Furthermore, Type II-C Cas9 orthologs have been identified that target protospacer adjacent motif sequences limited to between one-four required nucleotides.