Zhen Z Wu

8323651, Dec 4, 2012

May 8, 2009

12/437715

Jijie Gu - Shewsbury MA, US
Chung-Ming Hsieh - Newton MA, US
Zhen Wu - Framingham MA, US
Enrico L. DiGiammarino - Lindenhurst IL, US
Feng Luo - Arlington Heights IL, US
Gerard B. Fox - Barrington Hills IL, US
John E. Harlan - Lake Zurich IL, US
Martin Schmidt - Bensheim, DE
Ralf Loebbert - Speyer, DE
Reinhold Mueller - Schifferstadt, DE
Ulrich Ebert - Mannheim, DE
Volker Nimmrich - Heidelberg, DE

Abbott Laboratories - Abbott Park IL
Abbott GmbH & Co. KG - Wiesbaden-Delkenheim

A61K 39/395
C07H 21/04
C07K 16/00
A61P 25/28
C12N 15/63
C12N 5/10
C12P 21/02

4241431, 435 696, 4353201, 435325, 536 235, 53638822

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid β and advanced glycation-end-products.

20040178035, Sep 16, 2004

Mar 14, 2003

10/388883

Zhen Wu - New York NY, US

A45C013/00
A45C013/30

190/115000, 190/01800A

An article of luggage having an integral handle assembly generally has a front elongated segment, a back elongated segment, a first side segment, a second side segment, a top segment, and a bottom segment. Narrower side segments are disposed along side portions of the container relative to the top and bottom segments. A first support and a second support are affixed longitudinally to first side and second side segments, respectively. The handle assembly having a handle is disposed above the top segment and operatively engages the first and the second supports. For moving the luggage, a set of casters affixed on the bottom segment whereby the container may be rolled with a leading segment set at an incline relative to a substrate supporting the container. The leading segment may be one of the elongated segments or one of the side segments.

20050052650, Mar 10, 2005

Sep 3, 2004

10/933637

Zhen Wu - New York NY, US

G01R033/02

356364000

The present invention relates to a method and system for high spatial resolution measurement of a magnetic field or gradient. The method determines Zeeman polarization at a submicron distance from cell surfaces of an optical pumping cell using two laser beams. A strong pump beam produces Zeeman polarization in the vicinity of surfaces inside the optical pumping cell. The Zeeman polarization precesses around the magnetic field that is to be measured and is probed by the evanescent wave of a weak probe beam. The precessing Zeeman polarization can be monitored by measuring reflectivity of the probe beam at an interface between the active medium and the cell. The polarization can be used to measure the magnetic field or gradient. In one embodiment a second probe beam in the yz-plane is incident on the same position as the pump beam and the first probe beam that is in the xz-plane. Both probe beams undergo total internal reflection at an interface between the cell surface and the active medium. The reflectivities of the two probe beams are measured, from which the x, y and z components of the magnetic field can be determined simultaneously.

20100308814, Dec 9, 2010

Mar 29, 2010

12/749498

Zhen WU - New York NY, US

G01R 33/02

3242441

The present invention relates to a method and system for high spatial resolution measurement of a magnetic field or gradient. The method determines Zeeman polarization at a submicron distance from cell surfaces of an optical pumping cell using two laser beams. A strong pump beam produces Zeeman polarization in the vicinity of surfaces inside the optical pumping cell. The Zeeman polarization precesses around the magnetic field that is to be measured and is probed by the evanescent wave of a weak probe beam. The precessing Zeeman polarization can be monitored by measuring reflectivity of the probe beam at an interface between the active medium and the cell. The polarization can be used to measure the magnetic field or gradient. In one embodiment a second probe beam in the yz-plane is incident on the same position as the pump beam and the first probe beam that is in the xz-plane. Both probe beams undergo total internal reflection at an interface between the cell surface and the active medium. The reflectivities of the two probe beams are measured, from which the x, y and z components of the magnetic field can be determined simultaneously.

20170002075, Jan 5, 2017

Jul 18, 2016

15/213130

- WIESBADEN, DE
- NORTH CHICAGO IL, US
Zhen WU - Framingham MA, US
Enrico L. DiGIAMMARINO - Lindenhurst IL, US
Feng LUO - Arlington Heights IL, US
Gerard B. FOX - Barrington Hills IL, US
John E. HARLAN - Lake Zurich IL, US
Martin SCHMIDT - Bensheim, DE
Ralf LOEBBERT - Speyer, DE
Reinhold MUELLER - Schifferstadt, DE
Ulrich EBERT - Mannheim, DE
Volker NIMMRICH - Heidelberg, DE

C07K 16/28
C07K 16/46
C12P 21/00

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.