US Patent:
20100297004, Nov 25, 2010
Inventors:
Anna M. Wu - Sherman Oaks CA, US
Robert E. Reiter - Los Angeles CA, US
Eric J. Lepin - Los Angeles CA, US
James D. Marks - Kensington CA, US
Yu Zhou - San Francisco CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 51/10
C07K 16/00
C12N 9/96
C12N 15/13
C12N 5/09
A61K 39/395
A61K 49/00
A61B 5/055
A61P 35/00
US Classification:
424 149, 5303873, 5303917, 5303913, 435188, 536 2353, 435375, 4241351, 424 91, 424 934, 424 96
Abstract:
The present invention provides novel high affinity antibodies and fragments thereof that bind to the cancer antigen PSCA. The antibodies of the present invention may be used for cancer diagnosis, prognosis, treatment, visualization, and the like. The present invention also provides methods for the detection, visualization, and treatment of various cancers expressing PSCA.