Yu U Zhang

20110313066, Dec 22, 2011

May 16, 2011

13/108576

Jad Jaber - Sudbury MA, US
Wilson Moya - Concord MA, US
James Hamzik - Chelmsford MA, US
Arezki Boudif - Wakefield MA, US
Yu Zhang - Chelmsford MA, US
Neil Soice - Amherst NH, US
John Charkoudian - Carlisie MA, US
Nripen Singh - Burlington MA, US

Millipore Corporation - Billenca MA

B01J 39/20
C07K 1/36
C07K 1/30

521 31, 5303871, 5303881, 521 38

The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.

54591287, Oct 17, 1995

Oct 27, 1994

8/330218

Barrett Rollins - Brookline MA
Yu J. Zhang - Brookline MA

Dana-Farber Cancer Institute - Boston MA

C07K 1452
C08H 100
A61K 3819
A61K 4505

514 8

The invention relates to a human MCP-1 derivative, and pharmaceutical compositions thereof, wherein human MCP-1 has been modified such that the protein inhibits monocyte chemoattractant activity. Successful inhibition of the activity is found where the MCP-1 is modified in one or more of the following: a) the 28-tyrosine is substituted by aspartate, b) the 24-arginine is substituted by phenylalanine, c) the 3-aspartate is substituted by alanine, and/or d) the 2-8 amino acid sequence is deleted. The claimed MCP-1 derivatives can be administered to a patient in need of inhibiting MCP-1 monocyte chemoattractant activity. For example, the derivatives can be used to prevent restenosis, such as that which is common in a patient undergoing coronary artery angioplasty. The invention further relates to compositions and methods of inhibiting monocyte chemoattractant activity of MCP-1 employing the derivatives described.

20200261157, Aug 20, 2020

Feb 14, 2020

16/790989

- Santa Clara CA, US
Yu Zhang - Concord MA, US
Jeffrey A. Kasten - San Mateo CA, US

EchoPixel, Inc. - Santa Clara CA

A61B 34/10
A61F 2/24

A computer that determines at least an anatomic feature associated with an aortic valve is described. During operation, the computer generates a 3D image associated with an individual's heart. This 3D image may present a view along a perpendicular direction to a 2D plane in which bases of a noncoronary cusp, a right coronary cusp and a left coronary cusp reside. Then, the computer may receive information specifying a set of reference locations that are associated with an aortic-root structure. Next, the computer automatically determines, based, at least in part, on the set of reference locations, at least the anatomical feature, which is associated with an aortic valve of the individual and a size of an aortic-valve device used in a transcatheter aortic-valve replacement (TAVR) procedure.

20200265618, Aug 20, 2020

Feb 14, 2020

16/790955

- Santa Clara CA, US
Yu Zhang - Concord MA, US
Jeffrey A. Kasten - San Mateo CA, US

EchoPixel, Inc. - Santa Clara CA

G06T 11/00
A61B 34/10
G16H 30/40
G16H 50/50

A computer that determines at least an anatomic feature of a left atrial appendage (LAA) is described. During operation, the computer generates a 3D image associated with an individual's heart. This 3D image may present a view along a perpendicular direction to an opening of the LAA. Then, the computer may receive information specifying a set of reference locations. For example, the set of reference locations may include: a location on a circumflex artery, a location between a superior portion of the LAA and a left pulmonary vein, and/or a location on a superior wall of the LAA and distal to trabeculae carneae. Next, the computer automatically determines, based, at least in part, on the set of reference locations, at least the anatomical feature of the LAA, which is associated with the opening of the LAA and a size of a device used in an LAA closure (LAAC) procedure.

20200024560, Jan 23, 2020

Aug 31, 2018

16/119022

Yu Shrike Zhang - Cambridge MA, US
Ali Khademhosseini - Los Angeles CA, US

United States of America, as Represented by the Secretary of the Navy - Arlington VA

C12M 3/00
G01N 33/50
C12N 5/074
C12N 5/077
C12N 5/071
C12M 3/06

A bioreactor and methods for use can include a microfibrous scaffold, that can be made of a composite bioink, and that can have endothelial cells directly embedded within the scaffold using an additive manufacturing process. The scaffold can further be seeded with cardiomyocytes. The hydrogel scaffold can be composed of a plurality of serpentine layers, with each serpentine layers, which can be placed on each other in a cross-hatch configuration, so that the primary axes of successive layers are perpendicular. This configuration can establish an aspect ratio for the scaffold, which can be selectively varied. For greater strength, the successive layers that have a primary axis in the same direction can be placed in the scaffold so that they are slight offset from each other. The scaffold can be placed in the bioreactor with perfusion, for use in cardiovascular drug screening and other nanomedicine endeavors.

20200026765, Jan 23, 2020

Oct 3, 2017

16/338174

- Mountain View CA, US
Yu Zhang - Cambridge MA, US
Quoc V. Le - Sunnyvale CA, US
William Chan - Markham, CA

G06F 17/28
G10L 15/16
G10L 15/197
G06N 3/08

A computer-implemented method for training a neural network that is configured to generate a score distribution over a set of multiple output positions. The neural network is configured to process a network input to generate a respective score distribution for each of a plurality of output positions including a respective score for each token in a predetermined set of tokens that includes n-grams of multiple different sizes. Example methods described herein provide trained neural networks which produce results with improved accuracy compared to the state of the art, e.g. translations that are more accurate compared to the state of the art, or more accurate speech recognition compared to the state of the art.

20190390260, Dec 26, 2019

Feb 13, 2018

16/481964

- Boston MA, US
Jiazhi HU - Boston MA, US
Sherry LIN - Brookline MA, US
Zhou DU - Chestnut Hill MA, US
Yu ZHANG - West Roxbury MA, US
Huan CHEN - Cambridge MA, US

THE CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

C12Q 1/6827
C12Q 1/6869
G16B 30/00
C12Q 1/6858

Described herein are methods and assays for detection of recombination and/or rearrangement events in a cell. In some embodiments, the methods and/or assays relate to Linear Amplification Mediated (LAM)-PCR. In some embodiments, the recombination event is a V(D)J recombination event.

20190236451, Aug 1, 2019

Apr 10, 2019

16/380101

- Mountain View CA, US
Yu Zhang - Cambridge MA, US
William Chan - Markham, CA

G06N 3/08
G06N 3/04
G10L 15/16
G10L 15/02
G10L 15/22

A speech recognition neural network system includes an encoder neural network and a decoder neural network. The encoder neural network generates an encoded sequence from an input acoustic sequence that represents an utterance. The input acoustic sequence includes a respective acoustic feature representation at each of a plurality of input time steps, the encoded sequence includes a respective encoded representation at each of a plurality of time reduced time steps, and the number of time reduced time steps is less than the number of input time steps. The encoder neural network includes a time reduction subnetwork, a convolutional LSTM subnetwork, and a network in network subnetwork. The decoder neural network receives the encoded sequence and processes the encoded sequence to generate, for each position in an output sequence order, a set of substring scores that includes a respective substring score for each substring in a set of substrings.