Inventors:
Ying Yuan - Bellevue WA
Deborah D. Crane - Hamilton MT
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 3904
US Classification:
4242481, 424 91, 424 92, 424 931, 424 932, 4241841, 4242341, 435 681, 435 863, 435 864, 435 865, 435866, 435440, 435471
Abstract:
This invention provides for novel attenuated strains of and Attenuation is achieved by eliminating or by downregulating the expression of the -crystallin heat shock protein gene (âacr geneâ). The invention provides for vaccines and methods of vaccinating mammals for protection against Mycobacterium sp. that cause tuberculosis.