Yi Zhang

7619056, Nov 17, 2009

May 31, 2007

11/809034

Anthony East - Madison NJ, US
Michael Jaffe - Maplewood NJ, US
Yi Zhang - Harrison NJ, US
Luiz H Catalani - Carapicuiba, BR

New Jersey Institute of Technology - Newark NJ

C08G 59/50
C07D 493/02

528421, 549464

Novel thermoset epoxy polymers using the bisglycidyl ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, are disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. The anhydrosugars are derived from renewable sources and the bisglycidyl ethers are not xenoestrogenic and the thermoset curing agents are likewise derived form renewable resources.

7977050, Jul 12, 2011

Sep 2, 2005

11/218838

Michael Seul - Fanwood NJ, US
Nataliya Korzheva - Somerville NJ, US
Jiacheng Yang - Hillsborough NJ, US
Yi Zhang - Hillsborough NJ, US

Bioarray Solutions, Ltd. - Warren NJ

C12Q 1/68

435 6

A method mediated with in-vitro transcription (“IVT”) which permits miniaturization of multiplexed DNA and RNA analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7-tagged double stranded DNA: wherein, the selected strand forms the template for RNA synthesis. In one embodiment, double stranded DNA incorporating the T7 (or other) promoter sequence at the 3′ end or the 5′ end is produced, for example, by amplification of genomic DNA using the Polymerase Chain Reaction (PCR). Also disclosed are nested PCR designs permitting allele analysis in combination with strand selection by IVT. Further, in one embodiment of a homogeneous format for transcription-mediated amplification and multiplexed detection (which may be particularly suited for viral or pathogen detection), encoded microparticles display “looped” capture probe configurations permitting the generation of a signal upon capture of RNA product and real-time assay monitoring.

20070189990, Aug 16, 2007

Feb 16, 2006

11/355936

Anthony East - Madison NJ, US
Yi Zhang - Harrison NJ, US
Michael Jaffe - Maplewood NJ, US

A61K 8/49
C07D 307/02

424059000, 549478000

Esters of cinnamic acids with sugar alcohols and anhydro-sugar alcohols are described. The esters have ultraviolet light absorbing properties. In particular, the diester of ferulic acid with isosorbide is a UV-absorber derived from natural materials and has use as a UV-absorber for polymeric materials and as a UV-absorber for cosmetics.

20070243534, Oct 18, 2007

Apr 12, 2006

11/403100

Michael Seul - Fanwood NJ, US
Yi Zhang - Hillsborough NJ, US
Sukanta Banerjee - Pennington NJ, US
Jiacheng Yang - Hillsborough NJ, US
Chiu Chau - Edison NJ, US

C12Q 1/68
C12M 3/00

435006000, 435287200, 977924000

In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps: adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

20080021209, Jan 24, 2008

May 31, 2007

11/809035

Anthony East - Madison NJ, US
Michael Jaffe - Maplewood NJ, US
Yi Zhang - Harrison NJ, US
Luiz Catalani - Carapicuiba, BR

New Jersey Institute of Technology - Newark NJ

C07H 1/00

536124000

A novel method for the synthesis of ethers of anhydrosugars, such as isosorbide, isomannide, and isoidide, is disclosed. The bisglycidyl ethers are useful as substitutes for bisphenol A in the manufacture of thermoset epoxy ethers. Anhydrosugar ethers are derived from renewable sources and are not xenoestrogenic. Higher alkyl and aralkyl ethers are stable high-boiling oils that are good plasticizers for materials such as PVC.

20100267578, Oct 21, 2010

Feb 18, 2010

12/708362

MICHAEL SEUL - Fanwood NJ, US
Yi Zhang - Hillsborough NJ, US
Sukanta Banerjee - Pennington NJ, US
Jiacheng Yang - Hillsborough NJ, US
Chiu Chau - Edison NJ, US

BioArray Solutions, LLC - Warren NJ

C40B 30/04

506 9

In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method including a method for increasing the effective concentration of the nucleic acid targets at the surface of a bead to which the oligonucleotide probes are bound, by one or more of the following steps:adjusting assay conditions so as to increase the effective concentration of the targets available for binding to the probes, by one or more of the following: (i) selecting a particular probe density on the surface of the bead; (ii) selecting a solution having an ionic strength greater than a threshold; (ii) selecting a target domain of a size less than a threshold; or (iii) selecting target domains within a specified proximity to a terminal end of the targets.

20100298733, Nov 25, 2010

Jul 30, 2010

12/847698

Jonathan Kwok - Holmdel NJ, US
Marina Brockway - Shoreview MN, US
Kent Lee - Shoreview MN, US
Quan Ni - Shoreview MN, US
Yachuan Pu - San Diego CA, US
Jeffrey Stahmann - Ramsey MN, US
Yi Zhang - Plymouth MN, US
Jesse Hartley - White Bear Lake MN, US

A61B 5/08

600529

An evaluation of heart failure status is provided based on a disordered breathing index. Patient respiration is sensed and a respiration signal is generated. Disordered breathing episodes are detected based on the respiration signal. A disordered breathing index is determined based on the disordered breathing episodes. The disordered breathing index is trended and used to evaluate heart failure status. The disordered breathing index may be combined with additional information and/or may take into account patient activity, posture, sleep stage, or other patient information.

20120094298, Apr 19, 2012

Jul 8, 2011

13/179136

Michael Seul - Fanwood NJ, US
Nataliya Korzheva - Somerville NJ, US
Jiacheng Yang - Hillsborough NJ, US
Yi Zhang - Hillsborough NJ, US

BioArray Solutions Limited - Warren NJ

C12Q 1/68

435 612

A method mediated with in-vitro transcription (“IVT”) which permits miniaturization of multiplexed DNA and RNA analysis, and in which elongation-mediated multiplexed analysis of polymorphisms (eMAP) is used as the analysis step, is described. Also described is a method mediated with IVT is for selecting a designated strand from T7-tagged double stranded DNA: wherein, the selected strand forms the template for RNA synthesis. In one embodiment, double stranded DNA incorporating the T7 (or other) promoter sequence at the 3′ end or the 5′end is produced, for example, by amplification of genomic DNA using the Polymerase Chain Reaction (PCR). Also disclosed are nested PCR designs permitting allele analysis in combination with strand selection by IVT. Further, in one embodiment of a homogeneous format for transcription-mediated amplification and multiplexed detection (which may be particularly suited for viral or pathogen detection), encoded microparticles display “looped” capture probe configurations permitting the generation of a signal upon capture of RNA product and real-time assay monitoring.