Yi W Wang

6541625, Apr 1, 2003

Feb 9, 2001

09/779853

Alex Cimpoia - Montreal, CA
Yi Fong Wang - Lexington MA

BioChem Pharma, Inc. - Laval

C07H 1900

536 2714, 435 41, 435 87, 435 88, 435280, 536 221

The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of and anomers represented by the following formula A or formula B: wherein R is selected from the group consisting of C alkyl and C aryl and Bz is benzoyl. The process comprises hydrolyzing said mixture with an enzyme selected from the group consisting of Protease N, Alcalase, Savinase, ChiroCLEC-BL, PS-30, and ChiroCLEC-PC to stereoselectively hydrolyze predominantly one anomer to form a product wherein R is replaced with H. The process also includes the step of separating the product from unhydrolyzed starting material. Additionally, the functional group at the C4 position is stereoselectively replaced with a purinyl or pyrimidinyl or derivative thereof.

6743910, Jun 1, 2004

Feb 24, 2003

10/370470

Alex Cimpoia - Montreal, CA
Yi Fong Wang - Lexington MA

Biochem Pharma, Inc. - Laval

C07H 1900

536 2714, 536 221, 435 41, 435 87, 435 88, 435280

The invention is a process for stereoselectively producing a dioxolane nucleoside analogue from an anomeric mixture of and anomers represented by the following formula A or formula B: wherein R is selected from the group consisting of C alkyl and C aryl and Bz is benzoyl. The process comprises hydrolyzing said mixture with an enzyme selected from the group consisting of Protease N, Alcalase, Savinase, ChiroCLEC-BL, PS-30, and ChiroCLEC-PC to stereoselectively hydrolyze predominantly one anomer to form a product wherein R is replaced with H. The process also includes the step of separating the product from unhydrolyzed starting material. Additionally, the functional group at the C4 position is stereoselectively replaced with a purinyl or pyrimidinyl or derivative thereof.

7003343, Feb 21, 2006

Apr 1, 2002

10/109888

Richard Watts - New York NY, US
Yi Wang - Pittsburgh PA, US
Martin R. Prince - New York NY, US

Cornell Research Foundation, Inc. - Ithaca NY

A61B 5/05
G01V 3/00

600410, 600419, 324306

Current bolus chase magnetic resonance angiography is limited by the imaging time for each station. Tailoring the density of k-space sampling along the anterior-posterior direction of the coronal station allows a substantial decrease in scan time that leads to greater contrast bolus sharing among stations and consequently a significant improvement in image quality. Fast arterial-venous transit in the carotid arteries requires accurate, reliable timing of the acquisition to the bolus transit to maximize arterial signal and minimize venous artifacts. The rising edge of the bolus is not utilized in conventional elliptical-centric view ordering because the critical k-space center must be acquired with full arterial enhancement. The invention provides a recessed elliptical-centric view ordering scheme is introduced in which the k-space center is acquired a few seconds following scan initiation. The recessed view ordering is shown to be more robust to timing errors in a patient studies.

7123757, Oct 17, 2006

Jun 6, 2002

10/164502

Vladimir N. Kolmogorov - New York NY, US
Yi Wang - Pittsburgh PA, US
Ramin Zabih - New York NY, US

Cornell Research Foundation, Inc. - Ithaca NY

G06K 9/00

382128

An efficient navigator method is presented that substantially increases the scan efficiency while maintaining the motion suppression effectiveness in magnetic resonance imaging. The method is achieved by simultaneously acquiring different image volumes at different motion states of the subject being scanned. A scheduling algorithm is used to assign volumes to position bins of a motion histogram of the subject. The motion histogram is periodically updated and the volumes are reassigned to position bins.

7357851, Apr 15, 2008

Sep 30, 2003

10/674955

Terence Alan Reid - Abingdon, GB
Shridhara Alva Karinka - Chelmsford MA, US
Milind P. Nagale - Lowell MA, US
Yi Wang - Southborough MA, US
Gurdial Sanghera - Oxon, GB

Abbott Laboratories - Abbott Park IL

G01N 27/327

20440304, 2044031, 20440314

An electrochemical cell for detection and quantification of analytes in a liquid sample, particularly a liquid sample having a small volume. In a preferred embodiment, the electrochemical cell comprises an assembly of conducting layers and insulating layers. The electrochemical cell can be formed by depositing conducting materials and insulating materials in alternating layers on an insulating substrate. It is preferred that the layer furthest from the insulating substrate be an insulating layer to minimize the damage of the conducting layers during handling of the electrochemical cell. In another embodiment, the assembly of conducting layers and insulating layers can be formed on both major surfaces of the insulating substrate. The assembly can comprise at least one working electrode and at least one other electrode, e. g. , a dual-purpose reference/counter electrode.

7545967, Jun 9, 2009

Sep 17, 2003

10/664425

Martin R. Prince - New York NY, US
Ramin Zabih - New York NY, US
Yi Wang - Pittsburgh PA, US
Richard Watts - Christchurch, NZ
Junhwan Kim - Seoul, KR
Jeff Bezanson - Scarsdale NY, US
Hale Ersoy - Ankara, TR

Cornell Research Foundation Inc. - Ithaca NY

G06K 9/00

382130, 382128, 382131, 382280, 382284, 600425, 600429, 600410, 600419, 600407, 378 21, 378 27, 378 4, 378 62, 128920, 128922

In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.

7582764, Sep 1, 2009

May 26, 2006

11/442742

Li Deng - Newton MA, US
Hongming Li - Waltham MA, US
Yi Wang - Waltham MA, US
Fanghui Wu - Waltham MA, US

Brandeis University - Waltham MA

C07D 453/04

546134

One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an O-aryl group or an O-aroyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an optionally substituted O-diazene group or an optionally substituted O-benzoyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain a thiourea at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an NH(═S)NH-aryl group at the C9 position. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or prochiral imine, comprising the step of: reacting a prochiral alkene or imine with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. In certain embodiments, the nucleophile is a malonate or β-ketoester.

7734078, Jun 8, 2010

Jun 1, 2009

12/475797

Martin R. Prince - New York NY, US
Ramin Zabih - New York NY, US
Yi Wang - Pittsburgh PA, US
Richard Watts - Christchurch, NZ
Junhwan Kim - Seoul, KR
Jeff Bezanson - Scarsdale NY, US
Hale Ersoy - Chestnut Hill MA, US

Cornell Research Foundation, Inc. - Ithaca NY

G06K 9/00

382130, 382128, 382131, 382280, 382284, 600425, 600429, 600410, 600419, 600407, 378 21, 378 27, 378 4, 378 62

In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.