Yi Zhang Liu

7728135, Jun 1, 2010

Jan 5, 2006

11/326154

Xiongwei Shi - Edison NJ, US
Man Zhu - Clark NJ, US
William Leong - Westfield NJ, US
Vilas Dahanukar - Hyderabad, IN
Ilia A. Zavialov - Princeton NJ, US
Cecelia Proietti - Clark NJ, US
Shannon Zhao - Littleton MA, US
Hong-Chang Lee - Livingston NJ, US
Yi Liu - Clark NJ, US
Hoa N. Nguyen - Dayton NJ, US
Wenxue Wu - Princeton Junction NJ, US
Bosco D'Sa - Edison NJ, US
Feng Liang - Monmouth Junction NJ, US
Loc Thanh Tran - Parsippany NJ, US

Schering Corporation - Kenilworth NJ

C07D 401/14
C07D 403/12
A61K 31/506
A61K 31/18

544295, 544364, 544335

The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

8010176, Aug 30, 2011

Mar 30, 2007

11/731624

Lizhi Sun - Irvine CA, US
Yi Liu - Indianapolis IN, US
Zhiguo Wang - Iowa City IA, US
Ge Wang - Blacksburg VA, US

The Regents of the University of California - Oakland CA

A61B 5/00

600407, 600425, 600473, 382128, 382131, 382132, 378 37

A method for obtaining a distribution of a stiffness property in tissue includes applying a plurality of loadings to the tissue, obtaining a plurality of two-dimensional (2-D) imaging projections of the tissue from different directions, measuring a force resulting from one of the plurality of loadings, measuring from at least one of the plurality of 2-D imaging projections a displacement of the tissue in response to the force, obtaining an initial set of input parameters for an estimated stiffness property of the tissue, and solving iteratively for the stiffness property using a computer.

8101608, Jan 24, 2012

Nov 7, 2005

11/718886

Yongqin Wan - Irvine CA, US
Yuan Mi - San Diego CA, US
Yi Fan - Poway CA, US
Dai Cheng - San Diego CA, US
Yi Liu - San Diego CA, US
Nathanael S. Gray - Boston MA, US
Pamela Albaugh - Carlsbad CA, US

IRM LLC, a Delware Limited Corporation - Hamilton

A61K 31/404
A61K 31/4025
A61K 31/4178
A61K 31/4245
A61K 31/454
A61K 31/5377
A61K 31/496
C07D 401/14
C07D 403/14
C07D 405/06
C07D 405/14
C07D 413/06
C07D 413/14
C07D 471/04

5142352, 514339, 514397, 51425409, 514364, 514414, 548468, 5483121, 5482664, 546201, 544373, 544144

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

8546108, Oct 1, 2013

Jan 24, 2011

13/575222

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Allergan, Inc. - Irvine CA

C12N 9/52

435 711, 435 691, 435220, 435471

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

20030034489, Feb 20, 2003

Jul 16, 2002

10/195527

Surya Bhattacharya - Irvine CA, US
Ming Chen - Newport Coast CA, US
Liming Tsau - Irvine CA, US
Henry Chen - Irvine CA, US
Neal Kistler - Monarch Beach CA, US
Yi Liu - Union City CA, US
Tzu-Hsin Huang - San Jose CA, US

Broadcom Corporation

H01L023/58

257/048000

A semiconductor wafer configured for in-process testing of integrated circuitry fabricated thereon. At least two die are separated by a scribe area, and each of the die has at least one complementary metal oxide silicon (CMOS) static random access memory (SRAM) array embedded therein among mixed-signal CMOS circuitry. The mixed-signal CMOS circuitry includes devices with larger feature sizes compared to similar devices of the embedded SRAM array. A first process control monitor (PCM) testline is included, which has a first layout corresponding to the mixed-signal CMOS circuitry. Additionally, a second PCM testline is included, which has a second layout corresponding to the embedded SRAM arrays. The first and second PCM testlines are formed in the scribe area.

20100036125, Feb 11, 2010

Oct 16, 2009

12/580855

Xiongwei Shi - Edison NJ, US
Man Zhu - Clark NJ, US
William Leong - Westfield NJ, US
Vilas Dahanukar - Hyderabad, IN
Ilia A. Zavialov - Princeton NJ, US
Cecilia Proietti - Westfield NJ, US
Shannon Zhao - Littleton MA, US
Hong-Chang Lee - Livingston NJ, US
Yi Liu - Iselin NJ, US
Hoa N. Nguyen - Dayton NJ, US
Wenxue Wu - Princeton Junction NJ, US
Bosco D'Sa - Edison NJ, US
Feng Liang - Monmouth Junction NJ, US
Loc Thanh Tran - Piscataway NJ, US

C07D 401/06
C07D 211/30

544360, 546248

The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl--piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

20110189162, Aug 4, 2011

Dec 16, 2010

12/970239

Sanjiv Ghanshani - Irvine CA, US
Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

ALLERGAN, INC. - Irvine CA

A61K 38/48
C07H 21/00
A61K 8/66
A61Q 19/08
A61P 29/00
C12N 15/63
C12N 9/52

424 9467, 536 232, 4353201, 435220

The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins.

20140030759, Jan 30, 2014

Sep 26, 2013

14/038328

Linh Q. Le - Tustin CA, US
Yi Liu - Irvine CA, US
Lance E. Steward - Irvine CA, US

Allergan, Inc. - Irvine CA

C12P 21/00

435 681

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.