Yi M Liu

7375203, May 20, 2008

Apr 6, 2005

11/099855

Christopher M. Flores - Lansdale PA, US
Yi Liu - Jenkintown PA, US
Mary Lou Lubin - Norristown PA, US
Ning Qin - Blue Bell PA, US

Janssen Pharmaceutica N.V. - Beerse

C07H 21/02
C07H 21/04

536 231, 536 232, 536 234, 536 235

The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays and screening assays.

7575882, Aug 18, 2009

Oct 30, 2006

11/589340

Ning Qin - Blue Bell PA, US
Yi Liu - Jenkintown PA, US
Christopher M. Flores - Lansdale PA, US
Tasha Hutchinson - Green Lane PA, US
Michael P. Neeper - Collegeville PA, US

Janssen Pharmaceutica N. V. - Beerse

G01N 33/567
C07K 14/705

435 721, 435 72

It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

20090275649, Nov 5, 2009

Jul 9, 2009

12/499891

Ning Qin - Blue Bell PA, US
Yi Liu - Jenkintown PA, US
Christopher M. Flores - Lansdale PA, US
Tasha Hutchinson - Green Lane PA, US
Michael P. Neeper - Collegeville PA, US

A61K 31/352
G01N 33/53
C12Q 1/02
C12P 21/02
C12N 5/10
C12N 1/21
C12N 1/15
C12N 15/63
A61K 31/192
A61K 31/05
C07K 14/00
C07H 21/00

514454, 435 721, 435 29, 435 691, 435325, 4352523, 43525411, 4353201, 514568, 514729, 530350, 536 231

It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.

20190167116, Jun 6, 2019

Nov 15, 2018

16/192229

Yu Chen - College Park MD, US
Qinggong Tang - College Park MD, US
Udayakumar Kanniyappan - Hyattsville MD, US
Lin Z. Li - Aston PA, US
He Xu - Lansdowne PA, US
Yi Liu - College Park MD, US
Emily Conant - Philadelphia PA, US

A61B 5/00
A61B 1/07
A61B 1/04
A61B 1/06
A61B 1/00
A61B 10/02

In accordance with aspects of the present disclosure, an exemplary system includes a hollow probe having a lumen containing one or more excitation optical fiber(s) and one or more imaging optical fiber(s) where the probe is sized to access a person's body, a first light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of NADH in breast tissue, a second light source optically coupled to the excitation fiber(s) and configured to emit light that excites fluorescence of FAD in tissue such as breast tissue, an image capturing device optically coupled to the imaging fiber(s), and a controller configured to control the first light source and the image capturing device to capture NADH fluorescence signals/intensities while the probe is within the person's body and control the second light source and the image capturing device to capture FAD fluorescence signals/intensities while the probe is within the person's body.

20190091216, Mar 28, 2019

Aug 25, 2015

15/506445

- Park City UT, US
Nick Kaludov - Baltimore MD, US
Yi Liu - Baltimore MD, US
Martin Martinov - Baltimore MD, US

A61K 31/4709
A61K 45/06
A61P 33/06

A novel quantum-based computational process for drug discovery and design was used to identify potential novel liver-stage anti-malarial therapeutic molecules. The approach combined the latest big-data advances in high-throughput bioassay development with fundamental scientific knowledge to generate new pharmaceutical leads. Several molecules with no previous association with anti-parasitical activity were identified. These molecules and there use in prevention and/or treatment of infections are provided.