Yan U Liu

7277574, Oct 2, 2007

Jun 27, 2005

11/169107

Yan Liu - New York NY, US
John Kender - Leonia NJ, US

The Trustees of Columbia University in the City of New York - New York NY

G06K 9/62

382159, 707 7, 712300

Methods and systems for feature selection are described. In particular, methods and systems for feature selection for data classification, retrieval, and segmentation are described. Certain embodiments of the invention are directed to methods and systems for complement sort-merge tree (CSMT), fast-converging sort-merge tree (FSMT), and multi-level (ML) feature selection. Accurate and fast results may be obtained by the feature selection methods and systems described herein.

7790155, Sep 7, 2010

Jul 8, 2005

11/177790

Sylvia Christakos - Mendham NJ, US
Yan Liu - Bloomfield NJ, US
Teresita Bellido - Little Rock AR, US

University of Medicine and Dentistry of New Jersey - New Brunswick NJ

A61K 48/00
C12N 15/867
C12N 15/861
C12N 15/86

424 932, 435456, 514 44

The present invention provides novel compositions containing a calbindin-Dtherapeutic element, which is involved in the regulation of apoptosis, and may be administered for the prevention of an abnormal apoptosis response in cells. In particular the compositions and methods of the present invention may be used for the prevention or induction of apoptosis in such cells types as osteoblasts and osteocytes. Specifically, the compositions and methods of the present invention are useful for the prevention of diseases associated with glucocorticoid induced cell death. Specifically, the compositions and methods of the present invention may be useful in the prevention of glucocorticoid induced cell death in osteoblasts and the treatment of such conditions as glucocorticoid induced osteoporosis.

20090047287, Feb 19, 2009

Feb 16, 2007

12/278710

Julia Billiard - Collegeville PA, US
Yan Liu - Collegeville PA, US

Wyeth - Madison NJ

A61K 39/395
C12N 5/08
C12Q 1/48
C12Q 1/68
C07K 16/22
A61K 31/7105
C07K 14/51
A61P 19/08

4241391, 435377, 435 15, 435 6, 5303879, 514 44, 530350

This invention relates to modulating Ror activity (e.g., Ror2 protein activity) and/or 14-3-3 β to affect bone formation or resorption. The invention further relates to compositions and methods for the screening, diagnosis and development of therapies for bone-related disorders such as osteoporosis and bone fracture. Antibodies and antibody fragments directed to Ror2 protein are particularly useful in causing dimerization of Ror2 proteins, thereby leading to the activation of Ror2.

20130108863, May 2, 2013

Apr 15, 2011

13/583316

Richard A. Cooke - Farmingham MA, US
Nilesh Gunda - North Chelmsford MA, US
Steven Donnell - Burlington MA, US
Yan Liu - Arlington MA, US

C23C 14/48
H01B 5/14

428336, 428408, 20419234, 427140

In accordance with an embodiment of the invention, there is provided a coated graphite article. The article comprises graphite; and a conductive coating overlaying at least a portion of the graphite. The conductive coating comprises a through-thickness resistance of less than about 50 ohms as measured through the thickness of the graphite and the conductive coating. In accordance with another embodiment of the invention, there is provided a method for manufacturing a graphite article comprising a conductive coating. The method comprises treating graphite of the article with a reactive ion etch process; and after treating the graphite with the reactive ion etch process, applying the conductive coating over at least a portion of the graphite. In a further embodiment according to the invention, there is provided a method for refurbishing a graphite article comprising graphite and an overlaying conductive coating. The method comprises removing the overlaying conductive coating of the graphite article with a reactive ion etch process; and applying a new conductive coating over at least a portion of the graphite.

20130196869, Aug 1, 2013

Dec 27, 2012

13/728053

Quest Diagnostics Investments Incorporated - Wilmington DE, US
Anthony Sferruzza - San Clemente CA, US
Ke Zhang - San Clemente CA, US
Yan Liu - San Juan Capistrano CA, US
Renius Owen - San Juan Capistrano CA, US

Quest Diagnostics Investments Incorporated - Wilmington DE

C12Q 1/68

506 9, 506 16

Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.

20220189811, Jun 16, 2022

Dec 15, 2020

17/122959

- Billerica MA, US
Jakub RYBCZYNSKI - Arlington MA, US
Yan LIU - Lexington MA, US

H01L 21/683

Electrostatic chucks include multiple electrodes, each having a spiral shape surrounding a center of a surface of the electrostatic chuck, to provide a polyphase electrostatic chuck. Each electrode can be connected to a different phase of power. The spiral shapes can each avoid one another as well as avoiding holes or openings in the surface of the electrostatic chuck. The spiral shapes can be algorithmically determined using a processor. These electrostatic chucks can include three or more electrodes. Methods of manufacture of the electrostatic chucks include determining shapes for each of the electrodes and providing each of the electrodes.

20230082993, Mar 16, 2023

Jan 5, 2022

17/568991

- Billerica MA, US
William G. DEVINE - Woburn MA, US
R. Bruce DIEBOLD - Waltham MA, US
So Young HWANG - Lexington MA, US
Yan LIU - Boston MA, US
Sang-Ae SEUNG - Lexington MA, US
Miyong YONG - Belmont MA, US
Sewon KIM - Cambridge MA, US
Jaekyoo LEE - North Andover MA, US
Jong Sung KOH - Cambridge MA, US

A61K 31/4725
C07D 401/04
C07D 401/14
C07D 405/14
C07D 413/04
C07D 413/14
C07D 513/04
C07D 471/04
C07D 498/08
C07D 403/04
C07D 403/14
A61K 31/496
A61K 31/4375
A61K 31/5377
A61K 31/5386
A61K 31/517
A61K 31/675
C07F 9/6558

The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.

20230060192, Mar 2, 2023

Aug 29, 2022

17/898179

- Billerica MA, US
Nathan RICHARD - Peabody MA, US
Steven DONNELL - Burlington MA, US
Sara MERCHEL - San Jose CA, US
Caleb MINSKY - Medfield MA, US
Cerel MUNOZ - North Chelmsford MA, US
Yan LIU - Lexington MA, US

B32B 41/00
B32B 7/12
B32B 9/00
B32B 9/04
B32B 15/20
B32B 37/12

Described are techniques and equipment (apparatus) for processing an electrostatic chuck at controlled process conditions, including, as an example, for processing an electrostatic chuck during a step of curing an adhesive that forms a bond between two layers of the electrostatic chuck.