Inventors:
Dong Xiao - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Robert G. Aslanian - Rockaway NJ, US
Sylvia Degrado - Scotch Plains NJ, US
Xianhai Huang - Warren NJ, US
Wei Zhou - Scotch Plains NJ, US
Michael Sofolarides - Hoboken NJ, US
Xiao Chen - Edison NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 417/02
C07D 417/14
A61K 31/55
A61P 29/00
Abstract:
The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X, R, R, R, R, R, and Rare as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.