Inventors:
Xiaojing Wang - Livermore CA
Gerhard Sperl - Horsham PA
Paul Gross - Stockton CA
Rifat Pamukcu - Spring House PA
Gary A. Piazza - Doylestown PA
Assignee:
Cell Pathways, Inc. - Horsham PA
International Classification:
C07D47104
US Classification:
514248, 544105, 544184, 544180, 544235, 544236, 544237
Abstract:
[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y and Y are independently selected from the group consisting of (CH ) ,âC(X)âNHâ,â(CH ) âC(X)âOâ, and X is O or S; R is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; âAâ is a benzene ring fused with the pyridazine ring; and R is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.