Wei Wang

7371364, May 13, 2008

Aug 13, 2004

10/918009

Chun Li - Missouri City TX, US
Wei Wang - Sugar Land TX, US
Shi Ke - Missouri City TX, US

Board of Regents, The University of Texas System - Austin TX

A61K 51/00
A61K 38/00
A61K 38/12
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00

424 169, 514 9, 530317

The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.

8383751, Feb 26, 2013

Jun 29, 2011

13/171823

Wei Wang - League City TX, US
David Knoeppel - League City TX, US

Fina Technology, Inc. - Houston TX

C08F 18/00
C08F 20/68
C08F 220/12
C08L 25/02
C08L 33/02
C08L 35/02
C08L 39/04

526320, 5263292, 525203, 525221, 525222, 525241

A method of making a styrenic composition having a high melt strength including combining a styrenic monomer and a second monomer to form a combined mixture and subjecting the combined mixture to polymerization to obtain a styrenic co-polymer, wherein the second monomer comprises a hydroxyl functional group and wherein the styrenic composition has a greater melt strength than that of general purpose polystyrene.

20100290997, Nov 18, 2010

May 11, 2007

12/227185

Chun Li - Missouri City TX, US
Wei Wang - Sugar Land TX, US
Marites P. Melancon - Houston TX, US
Juri G. Gelovani - Houston TX, US
Jeffrey Myers - Houston TX, US

A61K 49/06
C07D 403/10
C12Q 1/02
A61K 49/00

424 93, 548455, 435 29, 424 91

The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer.

20120186825, Jul 26, 2012

Dec 19, 2011

13/329462

Wei Wang - Sugar Land TX, US
Colin Longfield - Sugar Land TX, US
David Merlau - Friendswood TX, US
Sebastian Ives - Pearland TX, US
Brad Bailey - Katy TX, US
Belinda D. Manning - Pearland TX, US

E21B 34/06
E21B 34/00

166373, 166321

A remote actuation tool equipped with an intermediate volumetric mechanism for enhanced tool durability in high pressure differential downhole environments. Valve segments of the tool are actuated by power available due to a pressure differential between atmospheric and hydrostatic chambers of the tool. Yet, the intermediate volumetric mechanism, whether in the form of a discrete chamber or a hydraulic line system, minimizes stresses of the differential pressure on tool hydraulics. Thus, failure rates are substantially reduced. So, for example, the tool may be reliably employed in downhole environments which present differential pressures in excess of about 30,000 PSI.

20120208911, Aug 16, 2012

Jan 11, 2012

13/347706

Wei Wang - League City TX, US
David W. Knoeppel - League City TX, US
Melissa Greenberg - Katy TX, US

FINA TECHNOLOGY, INC. - Houston TX

C08L 25/14
C08F 226/06
C08F 224/00
C08F 220/28
C08L 25/08
C08F 230/08
C08F 220/08
C08J 9/06
C08J 9/10
C08J 9/08
C08F 212/08
C08F 220/12

521 88, 526347, 526263, 526266, 526320, 5263292, 526279, 526272, 521147, 521 95, 521 97, 521 82, 521146

A method of making a foamable polystyrene composition includes combining a styrenic monomer and a co-monomer containing a polar functional group to obtain a mixture, subjecting the mixture to polymerization to obtain a styrenic co-polymer, and combining the styrenic co-polymer with a blowing agent in a foaming process to obtain foamed articles.

20120208913, Aug 16, 2012

Jan 11, 2012

13/347704

Wei Wang - League City TX, US
Jose M. Sosa - Deer Park TX, US
David W. Knoeppel - League City TX, US

FINA TECHNOLOGY, INC. - Houston TX

C08J 9/00
C08L 25/18

521117, 521147, 521130, 521133, 521128, 521139

Foamable polystyrene compositions with enhanced blowing agent solubility and methods of making such polystyrene compositions by incorporating a polar additive in styrenic polymer or copolymers.

20120244079, Sep 27, 2012

May 6, 2010

13/319012

Shi Ke - Houston TX, US
Michel Mawad - Houston TX, US
Wei Wang - Houston TX, US

BAYLOR COLLEGE OF MEDICINE - Houston TX

C07D 403/08
A61K 49/04
A61K 49/00

424 944, 548455, 424 96, 424 91

The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.

20130005852, Jan 3, 2013

Jun 29, 2011

13/171819

Wei Wang - League City TX, US
David K. Knoeppel - League City TX, US
Fengkui Li - Houston TX, US
Jose M. Sosa - Deer Park TX, US

Fina Technology, Inc. - Houston TX

C08L 63/00
C08L 35/02

523400, 525190

Polystyrene blends and methods of making polystyrene blends including combining a styrene monomer and an epoxy-functional comonomer to form a combined mixture, subjecting the combined mixture to polymerization to obtain a polystyrene copolymer and combining the polystyrene copolymer with a biodegradable polymer to obtain a polystyrene blend.