Inventors:
Alfredo C. Castro - Winchester MA, US
Wei Deng - Lexington MA, US
Kristopher M. Depew - Acton MA, US
Michael A. Foley - Chestnut Hill MA, US
Christian C. Fritz - Natick MA, US
Asimina T. Georges Evangelinos - Andover MA, US
Michael J. Grogan - Arlington MA, US
Nafeeza Hafeez - West Roxbury MA, US
Edward B. Holson - Newton Highlands MA, US
Brian T. Hopkins - Brookline MA, US
Nii O. Koney - Somerville MA, US
Tao Liu - Ashland MA, US
David A. Mann - Swampscott MA, US
Lisa A. Marcaurelle - Arlington MA, US
Daniel A. Snyder - Cambridge MA, US
Dennis J. Underwood - Jamaica Plain MA, US
Andrew A. Wylie - Brookline MA, US
Lin-Chen Yu - Wollaston MA, US
Linping Zhang - Lexington MA, US
Assignee:
Infinity Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 261/02
A61K 31/42
Abstract:
One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.