US Patent:
20110150830, Jun 23, 2011
Inventors:
Tomikazu Sasaki - Bothell WA, US
Henry Chiu-Yuen Lai - Seattle WA, US
Narendra Pal Singh - Lynnwood WA, US
Steve J. Oh - Mill Creek WA, US
Assignee:
WASHINGTON, UNIVERSITY OF - Seattle WA
International Classification:
A61K 38/20
C07K 7/00
A61K 38/08
A61P 35/00
A61P 27/02
A61P 13/12
A61P 19/02
A61P 37/06
A61P 3/10
A61P 1/00
A61P 31/00
US Classification:
424 852, 530300, 514 11, 514 193, 514 208, 514 186, 514 167, 514 24, 514 25, 514 44, 514 194, 514 65, 514 86, 514 96, 514 77
Abstract:
The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.