Shihui Liu Phones & Addresses
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Canonsburg, PA
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14516 Settlers Landing Ct, North Potomac, MD 20878 (301) 738-6795
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Gaithersburg, MD
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Rockville, MD
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Bethesda, MD
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Galveston, TX
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Clemson, SC
Publications
Us Patents
Human Cancer Therapy Using Engineered Matrix Metalloproteinase-Activated Anthrax Lethal Toxin That Targets Tumor Vasculatuture
View pageUS Patent:
20100168012, Jul 1, 2010
Filed:
Dec 14, 2007
Appl. No.:
12/519362
Inventors:
Stephen H. Leppla - Bethesda MD, US
Shihui Liu - Gaithersburg MD, US
Thomas H. Bugge - Bethesda MD, US
Brooke M. Curie - Washington DC, US
Shihui Liu - Gaithersburg MD, US
Thomas H. Bugge - Bethesda MD, US
Brooke M. Curie - Washington DC, US
Assignee:
The Government of the United States of America as Represented by the Secretary of the Department of - Rockville MD
International Classification:
A61K 38/16
A61P 35/00
A61P 35/00
US Classification:
514 12
Abstract:
The present invention provides methods for inhibiting tumor associated angiogenesis by administering a mutant protective antigen protein comprising a matrix metalloproteinase-recognized cleavage site in place of the native protective antigen furin-recognized site in combination with a lethal factor polypeptide comprising a protective antigen binding site. Upon cleavage of the mutant protective antigen by a matrix metalloproteinase, the lethal factor polypeptide is translocated into cancer and endothelial cells and inhibits tumor associated angiogenesis.