Inventors:
- Oakland CA, US
- Washington DC, US
Raymond LIM - Tustin CA, US
Ramin SALEHI-RAD - Encino CA, US
Assignee:
The Regents of the University of California - Oaklandca
United States Government Represented by the Department of Veterans Affairs - Washington DC
International Classification:
A61K 38/19
C07K 16/28
A61P 35/00
A61K 45/06
Abstract:
The present disclosure relates, in general, to methods for treating cancer comprising administering to a subject in need thereof an effective amount of CXCL9, CXCL10 or the combination, in combination with an immune checkpoint inhibitor. The CXCL9, CXCL10 or combination may be administered as a polypeptide, a polynucleotide or cells comprising a polynucleotide encoding CXCL9, CXCL10 or both. In one aspect, the treatment is amenable to patients with low or high mutational burden tumors.