Inventors:
- Valby, DK
Jun Yuan - Boston MA, US
Rajagopal Bakthavatchalam - Madison CT, US
Kevin J. Hodgetts - Framingham MA, US
Qin Guo - Waterford CT, US
Scott M. Capitosti - Perry OH, US
Jianmin Mao - Winchester MA, US
David J. Wustrow - Los Gatos CA, US
International Classification:
C07D 487/04
C07D 401/14
C07D 417/14
C07D 401/12
C07D 417/04
C07D 403/04
C07D 231/14
US Classification:
5142222, 544324, 514275, 544331, 544122, 5142365, 544350, 514249, 5483741, 514406, 5462754, 514341, 544333, 514256, 544295, 51425219, 544 3
Abstract:
5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.