Inventors:
Guqi Wang - Charlotte NC, US
Qi Long Lu - Charlotte NC, US
International Classification:
A61K 31/21
C07C 203/04
A61P 21/00
Abstract:
Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula:wherein,Ris ONO, CHONO, CHOH, CHOH, or CHCHCH, or H;Ris ONO, CHONO, CHOH, CHOH, CHCHCHor H; andRis ONO, CHONO, CHOH, CHOH, CHCHCHor H;wherein n is an integer from 0 to 9, n′ is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n′+n″≦9, and wherein at least one of R, R, and Ris an ester nitrate selected from the group consisting of ONO, CHONO, and combinations thereof.