Inventors:
Ronald J. Biediger - Houston TX, US
Qi Chen - Carmel IN, US
E. Radford Decker - Houston TX, US
George W. Holland - Houston TX, US
Jamal M. Kassir - Stafford TX, US
Wen Li - Pearland TX, US
Robert V. Market - Pearland TX, US
Ian L. Scott - Delanson NY, US
Chengde Wu - Pearland TX, US
Jian Li - The Woodlands TX, US
Assignee:
Encysive Pharmaceuticals, Inc. - New York NY
International Classification:
A61K 31/4412
US Classification:
514352, 514345, 514349, 546183, 546290, 546296, 546297
Abstract:
A method for the inhibition of the binding of αβintegrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which αβis involved.