Ping Wu Phones & Addresses
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10159 Woodrose Ln, Hghlnds Ranch, CO 80129 (303) 989-2258
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Highlands Ranch, CO
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10159 Woodrose Ln, Highlands Ranch, CO 80129
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Company / Classification
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Managing
Rocky Mountain Science & Engineering LLC
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Import and Export
133 Zenith Ave, Lafayette, CO 80026
(303) 664-1158
(303) 664-1158
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Us Patents
Targets For Detection Of Ischemia
View pageUS Patent:
20080305550, Dec 11, 2008
Filed:
Jan 23, 2006
Appl. No.:
11/814044
Inventors:
Hollie Huff - Denver CO, US
Shannon George - Spokane WA, US
Ping Wu - Aurora CO, US
Shannon George - Spokane WA, US
Ping Wu - Aurora CO, US
International Classification:
G01N 33/68
G01N 33/50
G01N 33/20
C07K 16/18
G01N 33/50
G01N 33/20
C07K 16/18
US Classification:
436 71, 436 86, 436 73, 5303871, 5303879
Abstract:
The subject application comprises methods for determining the occurrence of an ischemic event in a subject by determining an ischemia score based on the amount of at least two ischemia modified albumin markers. The ischemia modified albumin markers include complexes of fatty acids bound to albumin, albumin molecules with open Cys34 sites, albumin molecules that are products of oxidation at Cys34, albumin molecules with altered conformation or altered divalent metal binding due to the conformational change or oxidation at Cys34, and albumin molecules that have been oxidized at the N-terminus. Also included in the invention are ligands to each of the foregoing ischemia modified albumin markers. Further included are methods of determining the occurrence of an ischemic event by determining the amount of fatty acid that is complexed to albumin in a patient sample. In another embodiment, an ischemic event is determined by quantitating the relative amounts of reduced and oxidized forms of albumin Cys34. In an additional embodiment, an ischemic event is determined by observing whether a shift in albumin conformation has occurred which would reflect oxidized Cys34. Further, the invention comprises a method of determining an ischemic event by determining the amount of metal ion bound to the albumin metal ion binding sites.