Pei Wang from 1433 Kensington Dr, Fremont, CA 94539, age 53

Analysis And Control Of Parallel Chemical Reactions

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US Patent:

6489168, Dec 3, 2002

Filed:

Jan 29, 1999

Appl. No.:

09/239223

Inventors:

Pei Wang - San Jose CA
G. Cameron Dales - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 3110

US Classification:

436 37, 422 62, 422 93, 422130, 422131, 422196, 422197, 436 43, 436 85, 436147, 436159, 700266, 700268, 700269

Abstract:

Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course of a combinatorial chemical reaction. Reaction parameters associated with individual reactor vessels are changed in response to the value measured during the reaction. Reaction parameters include temperature, pressure, stirring speed. The reaction occurring in one or more reactor vessels is quenched in response to values measured during the reaction. The measured values are used to calculate experimental results including temperature change, pressure change, percent conversion of starting material, and viscosity. The measured values and experimental results are displayed. In another aspect, the invention features a method for controlling a combinatorial chemical reactor.

Analysis And Control Of Parallel Chemical Reactions

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US Patent:

6727096, Apr 27, 2004

Filed:

Nov 28, 2000

Appl. No.:

09/723720

Inventors:

Pei Wang - San Jose CA
G. Cameron Dales - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 3110

US Classification:

436 37, 422 62, 422130, 422196, 422197, 436 34, 436 43, 436 50, 436 55, 436 85, 436147, 436159, 700266, 700268, 700269

Abstract:

Computer programs and computer-implemented methods for monitoring the progress and properties of parallel chemical reactions. The invention repeatedly receives a measured value or values associated with the contents of each of a plurality of reactor vessels and displays the measured over the course of a combinatorial chemical reaction. Reaction parameters associated with individual reactor vessels are changed in response to the value measured during the reaction. Reaction parameters include temperature, pressure, stirring speed. The reaction occurring in one or more reactor vessels is quenched in response to values measured during the reaction. The measured values are used to calculate experimental results including temperature change, pressure change, percent conversion of starting material, and viscosity. The measured values and experimental results are displayed. In another aspect, the invention features a method for controlling a combinatorial chemical reactor.

Parallel Reactor With Internal Sensing And Method Of Using Same

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US Patent:

6864092, Mar 8, 2005

Filed:

Nov 28, 2000

Appl. No.:

09/723926

Inventors:

Howard Turner - Campbell CA, US
G. Cameron Dales - Palo Alto CA, US
Lynn VanErden - Livermore CA, US
Johannes A. M. VanBeek - New Orleans LA, US
Damian A. Hajduk - San Jose CA, US
Ralph B. Nielsen - San Jose CA, US
Paul Mansky - San Francisco CA, US
Leonid Matsiev - Cupertino CA, US
Pei Wang - San Jose CA, US
Eric McFarland - Santa Barbara CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N031/10

US Classification:

436 37, 422 62, 422102, 422104, 422130, 422131, 422135, 436 85, 436147, 436159

Abstract:

Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

Parallel Reactor With Internal Sensing And Method Of Using Same

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US Patent:

6890492, May 10, 2005

Filed:

Nov 28, 2000

Appl. No.:

09/724276

Inventors:

Howard Turner - Campbell CA, US
G. Cameron Dales - Palo Alto CA, US
Lynn VanErden - Livermore CA, US
Johannes A. M. Van Beek - New Orleans LA, US
Damian A. Hajduk - San Jose CA, US
Ralph B. Nielsen - San Jose CA, US
Paul Mansky - San Francisco CA, US
Leonid Matsiev - Cupertino CA, US
Pei Wang - San Jose CA, US
Eric McFarland - Santa Barbara CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01J019/00
B01F007/00

US Classification:

422130, 366244, 366249, 366251, 366252, 366273, 366279, 422131, 422135, 422138, 436 37

Abstract:

Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

Graphic Design Of Combinatorial Material Libraries

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US Patent:

7199809, Apr 3, 2007

Filed:

Oct 18, 1999

Appl. No.:

09/420334

Inventors:

Steven D. Lacy - Sunnyvale CA, US
Eric W. McFarland - Santa Barbara CA, US
Adam L. Safir - Berkeley CA, US
Stephen J. Turner - San Jose CA, US
Lynn Van Erden - Livermore CA, US
Pei Wang - San Jose CA, US

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G06F 3/00
G06F 19/00

US Classification:

345700, 702 19

Abstract:

Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations replying arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of on components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.

Modified Glycoproteins And Uses Thereof

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US Patent:

8025879, Sep 27, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507044

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C07K 14/00
C07K 16/18

US Classification:

4241331, 5303873, 530395

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

Modified Host Cells And Uses Thereof

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US Patent:

8080415, Dec 20, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507046

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C12M 1/00

US Classification:

435334, 4352891, 435358

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

Methods For Generating Host Cells

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US Patent:

8084222, Dec 27, 2011

Filed:

Jul 21, 2009

Appl. No.:

12/507051

Inventors:

Cheng Liu - Richmond CA, US
Jingyi Xiang - Walnut Creek CA, US
Su Yan - Albany CA, US
Pei Wang - Fremont CA, US
Wei Chan Tai - Emeryville CA, US

Assignee:

Eureka Therapeutics, Inc. - Emeryville CA

International Classification:

C12Q 1/68
G01N 33/53

US Classification:

435 721, 435 29

Abstract:

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.