John J. Baldwin - Gwynedd Valley PA Richard L. Tolman - Warren NJ Mu T. Wu - Clark NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D49504 A61K 31505 A61K 31535
US Classification:
514254
Abstract:
There are disclosed certain 2-substituted-4-substituted 6H-7,8-dihydrothiapyrano[3,2-d]pyrimidines which have oral hypoglycemic activity and with such ability to lower blood sugar are useful in the treatment of type II diabetes and/or obesity with associated insulin resistance. Processes for the preparation of such compounds and compositions containing such compounds as the active ingredient thereof are also disclosed. The compounds are also. beta. -adrenergic blocking agonists or. alpha. -adrenergic blocking agents and act as ocular antihypertensives and are useful for the treatment of glaucoma and other eye disorders.