Ming Yin Chen

6369139, Apr 9, 2002

Nov 24, 1997

08/977097

Frederick D. Osterholtz - Pleasantville NY
Eric R. Pohl - Mt. Kisco NY
Ming J. Chen - Garnerville NY
Antonio Chaves - White Plains NY

Crompton Corporation - Middlebury CT

C08K 51515

524114, 1062871, 10628713, 10628714, 10628716, 10628722, 524107

The present invention provides stable epoxy silane emulsions and methods for the preparation of such compositions comprising (I) a water insoluble or slightly soluble epoxysilane; (II) an emulsifier; (III) water; and (IV) a water dispersible polymer containing a functional group with an active hydrogen. Also provided are two part systems such that an epoxysilane emulsion comprising components (I)-(III) are combined and the component (IV) may be added upon use of components (I)-(III). Moreover, additional components (V), such as catalysts and pH buffers, may be added. Such compositions may be used for, among other things, coatings, adhesives and sealants.

20090270397, Oct 29, 2009

Apr 8, 2009

12/384777

Seth J. Orlow - New York NY, US
Ming Chen - Wayne NJ, US

A61K 31/53
A61K 31/4188
A61K 31/505
A61K 31/517
A61K 31/4985
A61K 31/4965
A61P 35/00

514245, 514393, 514275, 5142664, 514249, 51425506

A method of potentiating the efficacy of an antineoplastic agent such as temozolomide, comprises the administration of an antifolate agent as defined herein. Also disclosed are compositions, including pharmaceutical compositions, comprising the antineoplastic agent and an antifolate agent, and the use of such compounds and compositions thereof to treat a variety of cancers, such as melanoma. Unit dosage forms and kits are also contemplated and disclosed.

56865236, Nov 11, 1997

Oct 6, 1995

8/540142

Ming J. Chen - Garnerville NY
Frederick D. Osterholtz - Pleasantville NY
Eric R. Pohl - Mt. Kisco NY
Antonio Chaves - White Plains NY

OSi Specialties, Inc. - Greenwich CT

C08L 4304

524547

Stable alkoxy silane containing compositions and methods for the preparation of a stable silane containing compositions comprising: (I) a water insoluble or slightly soluble alkoxy silane; (II) emulsifier; (III) water; and (IV) water dispersible or emulsified polymer containing an alkoxy silane functional group. Also provided are two part systems such that an alkoxy silane emulsion comprising components (I)-(III) are combined and the component (IV) may be added upon use of components (I) to (III). Moreover, additional components, (V), such as catalysts and pH buffers may be added.

56210388, Apr 15, 1997

May 26, 1995

8/452163

Ming J. Chen - Garnerville NY
Frederick D. Osterholtz - Pleasantville NY

Osi Specialties, Inc. - Danbury CT

C08L 8304

524547

Curable composition comprising a stable, water dispersible, curable polymer containing a sterically hindered alkoxylated silane group at 0. 1 to 75 weight percent of the total composition; a water dispersible or water soluble, hydrolytically stable organometallic catalyst, at 0. 1 to 10 weight percent of the total composition; and water at 99. 8 to 24. 9 weight percent of the total composition are taught herein. These compositions are useful as adhesives, sealants and paints. The compositions have improved properties including solvent resistance, adhesion, hardness, abrasion resistance and mar resistance. Particular catalysts for use herein include dihydroxy bis [2-hydroxypropanato (2-)-O. sup. 1,O. sup. 2 ] titanate, mixed titanium ortho ester complexes, acetylacetonate chelate, bis(ethyl-3-oxobutanolato-O. sup. 1,O. sup. 3) bis(2-propanolato) titanium, alkanolamine complex of titanium and mercaptoalcohol, mercaptide or sulfide forms of diorganotins having either a Sn--S or Sn. dbd. S bond.

62219383, Apr 24, 2001

Apr 4, 2000

9/543020

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

OSi Specialities Inc. - Tarrytown NY

C08F 800

524114

A method of preparing a coating or a sealant wherein a class of epoxysilanes; optionally, an emulsifier; water; a polymer containing a functional group with an active hydrogen; and a curing catalyst are mixed together.

61274623, Oct 3, 2000

Jul 30, 1997

8/902127

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

OSi Specialities, Inc. - Greenwich CT

C08F 800

524114

The present invention provides stable epoxy silane solutions and emulsions and methods for the preparation of stable epoxy-silane solutions and emulsions comprising: (I) a water insoluble or slightly soluble epoxysilane; (II) optionally, an emulsifier; (III) water; (IV) a water dispersible polymer containing a functional group with an active hydrogen; and (V) a catalyst. Also provided are two part systems such that an epoxysilane solution or emulsion comprising components (I)-(III) are combined and the components (IV) and (V) may be added upon use of components (I) to (III). Moreover, additional components, such as pH buffers may be added. Said compositions may be used for, among other things, coatings, adhesives and sealants. The water epoxy functional silane for use herein are of the general structure R. sup. 1. sub. a R. sup. 2. sub. b Si(OR. sup. 3). sub. 4-a-b where R. sup.

53933303, Feb 28, 1995

Jun 30, 1993

8/084867

Ming J. Chen - Garnerville NY
Antonio Chaves - White Plains NY

OSi Specialties, Inc. - Danbury CT

C09D 520

106 2

The present invention teaches masonry water repellents comprising aqueous emulsions of alkylalkoxysilanes with either a quaternary ammonium surfactant or a mixture of a quaternary ammonium surfactant with an amino and/or a nonionic surfactant. The alkylalkoxysilane is present at a level of about one to sixty weight percent of the final solution weight. The surfactants are present at levels of about 0. 05 to 25 weight percent of the final solution weight. The useful quaternary ammonium surfactants are alkyltrimethyl or dialkyldimethyl ammonium compounds or quaternary ammonium modified dimethylpolysiloxanes. Amino and nonionic surfactants are used as additives to the quaternary surfactants. The types of nonionic surfactants contemplated herein are alkylamines and alkyl acetylenic alcohols.

58279229, Oct 27, 1998

Feb 28, 1997

8/808113

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

OSi Specialties, Inc. - Greenwich CT

C08L 8300

524837

Curable composition comprising a stable, water dispersible, curable polymer containing a sterically hindered alkoxylated silane group at 0. 1 to 75 weight percent of the total composition; a water dispersible or water soluble, hydrolytically stable organotin catalyst, at 0. 1 to 10 weight percent of the total composition; and water at 99. 8 to 24. 9 weight percent of the total composition are taught herein. These compositions are useful as adhesives, sealants and paints. The compositions have improved properties including solvent resistance, adhesion, hardness, abrasion resistance and mar resistance. Particular catalysts for use herein include mercaptoalcohol, mercaptide and sulfide forms of diorganotins having either a Sn--S or Sn. dbd. S bond, and include dibutyltin dimercaptide and dibutyltin bis(1-thioglycerol).