Min Lu

7179468, Feb 20, 2007

Jun 8, 2001

09/877606

Min Lu - New York NY, US
Hong Ji - New York NY, US

Cornell Research Foundation, Inc. - Ithaca NY

A61K 39/21

4241881, 4241921, 4242081, 530300, 530350

The present invention provides polypeptides comprising a stabilized trimer of the carboxyl-terminal core region of the ectodomain of an enveloped virus, such as HIV. A subject polypeptide comprises three monomers that form a trimeric coiled coil in a prefusogenic conformation of an enveloped virus such as HIV. The subject polypeptides are useful as vacciness against enveloped virus, such as HIV, which vaccines are also provided. The present invention also provides methods of vaccinating an individual to prevent or treat HIV infection or prevent or treat infection by another enveloped virus, using a subject vaccine. Antibodies or binding portions thereof raised against a C-terminus trimeric coiled coil motif of an HIV gp41 ectodomain, or carboxyl-terminal core region of the ectodomain of another enveloped virus, are also provided as are methods of making such antibodies. Methods for detecting HIV or other enveloped viruses in a sample, as well as methods of screening for drugs which can inhibit HIV infection or other enveloped virus infection, are also provided by the present invention.

8130662, Mar 6, 2012

Dec 31, 2006

11/618894

Burwell Goode - Weston CT, US
Min Lu - Freehold NJ, US
Leopold Strahs - Williamsburg VA, US

AT&T Intellectual Property II, L.P. - Atlanta GA

G01R 31/08
G06F 11/00
H04L 12/28
H04L 12/56

370252, 37039521, 370401

A method and apparatus for providing a centralized or regionalized transcoding function are disclosed. For example, the method detects a codec mismatch during a call setup between a calling party endpoint device and a called party endpoint device. The method then invokes a transcoding function directly by at least one border element (BE) to handle the detected mismatch, where the transcoding function is performed by at least one centralized or regionalized transcoding server and at least one media resource.

20050089526, Apr 28, 2005

Sep 6, 2002

10/489040

John Moore - New York NY, US
James Binley - San Diego CA, US
Min Lu - New York NY, US
William Olson - New York NY, US
Norbert Schulke - New City NY, US
Jason Gardner - Ardsley NY, US
Paul Maddon - Scarsdale NY, US
Rogier Sanders - Amsterdam, NL

A61K039/21
C07K014/16

424188100, 530395000

This invention provides stable HIV-1 pre-fusion envelope glycoprotein trimeric complexes. This invention also provides related polypeptides and compositions comprising pharmaceutically acceptable particles and the trimeric complexes operably affixed thereto. This invention further provides related nucleic acids, vectors, host cells, compositions, production methods, and prophylactic and therapeutic methods.

20070134221, Jun 14, 2007

Nov 22, 2005

11/285794

Min Lu - New York NY, US

A61K 38/54
C12N 9/99

424094300, 435184000

The invention provides peptide inhibitors of HIV infection and methods for stabilizing those peptides.

20090171592, Jul 2, 2009

Dec 4, 2008

12/327867

Dax Fu - Leonia NJ, US
Min Lu - Lake Bluff IL, US

Brookhaven Science Associates, LLC - Upton NY

G06F 19/00

702 19

The present invention is a method of identifying a compound that has a sufficient level of binding with a target site on a mammalian zinc transporter, or a portion thereof. The method comprises (a) providing a homology model of a mammalian zinc transporter, or portion thereof, comprising at least one target site; and (b) employing computational means to evaluate the level of binding of the compound with the target site, or a portion thereof. If a sufficient level of binding is found, then a compound is identified.